FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301497321> ?p ?o ?g. }

• W4301497321 endingPage "54" @default.
• W4301497321 startingPage "50" @default.
• W4301497321 abstract "The only effective therapy for patients with metastatic soft tissue sarcoma in the lung is surgical resection, with a 5-year survival of approximately 25%. Because systemic chemotherapy has not significantly affected survival in these patients, we began to investigate locoregional chemotherapy. We have previously shown that isolated single lung perfusion with doxorubicin in the rat results in higher lung tissue levels and lower systemic toxicity than does high-dose intravenous therapy. In the present study, we examined the safety of isolated lung perfusion with doxorubicin and its efficacy in the treatment of experimental pulmonary metastases from soft tissue sarcoma. In experiment 1, 15 F344 rats were randomized into three groups ( n = 5): group I had isolated left lung perfusion with doxorubicin 320 μg/ml in saline solution; group II had left isolated lung perfusion with doxorubicin 480 μg/ml and group III with doxorubicin 640 μg/ml. All perfusions with doxorubicin were at 0.5 ml/min for 10 minutes followed by perfusion of saline solution for 5 minutes. On day 21, all animals underwent right (contralateral) pneumonectomy and were observed for over 10 days. In experiment 2, two groups of F344 rats were injected intravenously with 10 7 viable methylcholanthrene-induced sarcoma cells on day 0. On day 7, group I ( n = 12) had left isolated lung perfusion with saline solution only and group II ( n = 15) had isolated lung perfusion with doxorubicin 320 μg/ml. On day 21, all animals were killed, and their lungs were stained for metastases. Routine histologic sections from three animals from group II were examined. In experiment 1, 80% of the animals in group I survived contralateral pneumonectomy. There were no survivors in groups II and III. In experiment 2, three animals died after isolated lung perfusion (one from group I and two from group II), and one animal (group I) was excluded because of mediastinal tumor. All animals in both groups had massive tumor replacement of the right (untreated) lung. Group I animals had massive tumor replacement of the left (treated) lung, whereas animals in group II had eradication of metastases in nine of ten cases; no microscopic evidence of tumor was detected in all three animals evaluated for microscopic disease. Isolated lung perfusion with doxorubicin 320 μg/ml is safe and effective in eradicating experimental pulmonary sarcoma metastases in this model. (J T HORAC C ARDIOVASCSURG1994;107:50-4)" @default.
• W4301497321 created "2022-10-05" @default.
• W4301497321 creator A5015014900 @default.
• W4301497321 creator A5020614443 @default.
• W4301497321 creator A5026502766 @default.
• W4301497321 creator A5080828667 @default.
• W4301497321 date "1994-01-01" @default.
• W4301497321 modified "2023-09-30" @default.
• W4301497321 title "Isolated single lung perfusion with doxorubicin is effective in eradicating soft tissue sarcoma lung metastases in a rat model" @default.
• W4301497321 cites W1882520884 @default.
• W4301497321 cites W1970786602 @default.
• W4301497321 cites W1970880370 @default.
• W4301497321 cites W2013249489 @default.
• W4301497321 cites W2017897250 @default.
• W4301497321 cites W2036609907 @default.
• W4301497321 cites W2048914158 @default.
• W4301497321 cites W2055018123 @default.
• W4301497321 cites W2065200261 @default.
• W4301497321 cites W2105886206 @default.
• W4301497321 cites W2263318751 @default.
• W4301497321 cites W2344981287 @default.
• W4301497321 cites W40082302 @default.
• W4301497321 cites W4249995064 @default.
• W4301497321 doi "https://doi.org/10.1016/s0022-5223(94)70452-x" @default.
• W4301497321 hasPublicationYear "1994" @default.
• W4301497321 type Work @default.
• W4301497321 citedByCount "41" @default.
• W4301497321 countsByYear W43014973212013 @default.
• W4301497321 countsByYear W43014973212014 @default.
• W4301497321 countsByYear W43014973212016 @default.
• W4301497321 countsByYear W43014973212017 @default.
• W4301497321 countsByYear W43014973212022 @default.
• W4301497321 crossrefType "journal-article" @default.
• W4301497321 hasAuthorship W4301497321A5015014900 @default.
• W4301497321 hasAuthorship W4301497321A5020614443 @default.
• W4301497321 hasAuthorship W4301497321A5026502766 @default.
• W4301497321 hasAuthorship W4301497321A5080828667 @default.
• W4301497321 hasBestOaLocation W43014973211 @default.
• W4301497321 hasConcept C126322002 @default.
• W4301497321 hasConcept C126894567 @default.
• W4301497321 hasConcept C141071460 @default.
• W4301497321 hasConcept C142724271 @default.
• W4301497321 hasConcept C146957229 @default.
• W4301497321 hasConcept C2776694085 @default.
• W4301497321 hasConcept C2777397205 @default.
• W4301497321 hasConcept C2777589429 @default.
• W4301497321 hasConcept C2777714996 @default.
• W4301497321 hasConcept C2778256501 @default.
• W4301497321 hasConcept C2778629024 @default.
• W4301497321 hasConcept C2781303535 @default.
• W4301497321 hasConcept C42219234 @default.
• W4301497321 hasConcept C71924100 @default.
• W4301497321 hasConceptScore W4301497321C126322002 @default.
• W4301497321 hasConceptScore W4301497321C126894567 @default.
• W4301497321 hasConceptScore W4301497321C141071460 @default.
• W4301497321 hasConceptScore W4301497321C142724271 @default.
• W4301497321 hasConceptScore W4301497321C146957229 @default.
• W4301497321 hasConceptScore W4301497321C2776694085 @default.
• W4301497321 hasConceptScore W4301497321C2777397205 @default.
• W4301497321 hasConceptScore W4301497321C2777589429 @default.
• W4301497321 hasConceptScore W4301497321C2777714996 @default.
• W4301497321 hasConceptScore W4301497321C2778256501 @default.
• W4301497321 hasConceptScore W4301497321C2778629024 @default.
• W4301497321 hasConceptScore W4301497321C2781303535 @default.
• W4301497321 hasConceptScore W4301497321C42219234 @default.
• W4301497321 hasConceptScore W4301497321C71924100 @default.
• W4301497321 hasIssue "1" @default.
• W4301497321 hasLocation W43014973211 @default.
• W4301497321 hasOpenAccess W4301497321 @default.
• W4301497321 hasPrimaryLocation W43014973211 @default.
• W4301497321 hasRelatedWork W1830023854 @default.
• W4301497321 hasRelatedWork W2126540415 @default.
• W4301497321 hasRelatedWork W2397738413 @default.
• W4301497321 hasRelatedWork W2418461214 @default.
• W4301497321 hasRelatedWork W2616421371 @default.
• W4301497321 hasRelatedWork W2807122136 @default.
• W4301497321 hasRelatedWork W2904628587 @default.
• W4301497321 hasRelatedWork W2911209402 @default.
• W4301497321 hasRelatedWork W4254190769 @default.
• W4301497321 hasRelatedWork W4385423747 @default.
• W4301497321 hasVolume "107" @default.
• W4301497321 isParatext "false" @default.
• W4301497321 isRetracted "false" @default.
• W4301497321 workType "article" @default.