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- W4301498529 abstract "Abstract Panic disorder (PD) is characterized by uncontrollable fear accompanied by somatic symptoms that distinguish it from other anxiety disorders. Neural mechanisms underlying these unique symptoms are not completely understood. Here we report that the pituitary adenylate cyclase-activating polypeptide (PACAP)-expressing neurons in the lateral parabrachial nucleus projecting to the dorsal raphe (DR) are critical for panic-like behavioral and physiological alterations. These neurons are activated by panicogenic stimuli, but inhibited in conditioned fear and anxiogenic conditions. Activating these neurons elicits strong defensive behaviors and rapid cardiorespiratory increase without creating aversive memory, whereas inhibiting them attenuates panic-associated symptoms. Chemogenetic or pharmacological inhibition of downstream DR PACAP receptor-expressing neurons completely abolishes panic-like symptoms, thus demonstrating that the pontomesencephalic PACAPergic pathway mediates panicogenesis, and thereby identifying a promising therapeutic target for treating PD." @default.
- W4301498529 created "2022-10-05" @default.
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- W4301498529 date "2022-08-10" @default.
- W4301498529 modified "2023-09-28" @default.
- W4301498529 title "The neural basis of panic-like behavioral and somatic symptoms and their rescue in mice" @default.
- W4301498529 doi "https://doi.org/10.21203/rs.3.rs-1840169/v1" @default.
- W4301498529 hasPublicationYear "2022" @default.
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