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- W4301508717 abstract "Objective. Available data on the diagnostic value of determination of the concentration N-terminal pro-C-type natriuretic peptide (Nt-proCNP) to predict pulmonary hypertension (PH) in patients with COPD are few. Aim. To determine the concentration of NT-proCNP in COPD patients and evaluate its diagnostic value for the prediction of PH in COPD. Methods. The study involved 47 patients with COPD (GOLD II-IV, age 59,49±0,63 years, disease duration 13,7±0,63 years, smoking history 23,09±0,93 packs/years). NT-proCNP concentration in serum was assessed by ELISA technique (test Biomedica Medizinprodukte GmbH & Co KG, Austria). The pulmonary artery systolic pressure (SPAP) was analyzed by using a color-Doppler technique. Results. Concentrations of NT-proCNP were significantly higher in COPD patients with PH (SPAP 40-55 mmHg, n=16) or severe PH (SPAP ≥55 mmHg, n=10) than in patients without PH (SPAP < 40 mmHg, n=21): 4.14±0.51 pg/ml, 5.26±0.21 pg/ml and 1.42±0.03 pg/ml (p<0.001), respectively. A significant correlation was found between the concentration of NT-proCNP and SPAP (r=0.53; p<0.05). The AUC for Nt-proCNP levels to predict PH and severe PH in COPD were 0.928 and 0.932, respectively. Conclusion. The present study shows that the serum levels of NT-proCNP are significantly elevated in COPD patients with PH and can be used as a non-invasive specific biomarker for predicting PH in COPD." @default.
- W4301508717 created "2022-10-05" @default.
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- W4301508717 date "2015-12-30" @default.
- W4301508717 modified "2023-09-27" @default.
- W4301508717 title "THE ROLE OF N-TERMINAL PRO-C-TYPE NATRIURETIC PEPTIDE AS A DIAGNOSTIC BIOMARKER OF PULMONARY HYPERTENSION IN COPD PATIENTS" @default.
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- W4301508717 doi "https://doi.org/10.38109/2225-1685-2015-4-26-31" @default.
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