Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301585429> ?p ?o ?g. }
- W4301585429 abstract "Under physiological conditions, neuronal network synchronization leads to different oscillatory EEG patterns that are associated with specific behavioral and cognitive functions. Excessive synchronization can, however, lead to focal or generalized epileptiform activities. It is indeed well established that in both epileptic patients and animal models, focal epileptiform EEG patterns are characterized by interictal and ictal (seizure) discharges. Over the last three decades, employing in vitro and in vivo recording techniques, several experimental studies have firmly identified a paradoxical role of GABA A signaling in generating interictal discharges, and in initiating—and perhaps sustaining—focal seizures. Here, we will review these experiments and we will extend our appraisal to evidence suggesting that GABA A signaling may also contribute to epileptogenesis, i.e., the development of plastic changes in brain excitability that leads to the chronic epileptic condition. Overall, we anticipate that this information should provide the rationale for developing new specific pharmacological treatments for patients presenting with focal epileptic disorders such as mesial temporal lobe epilepsy (MTLE)." @default.
- W4301585429 created "2022-10-05" @default.
- W4301585429 creator A5007468350 @default.
- W4301585429 creator A5023924529 @default.
- W4301585429 creator A5027294480 @default.
- W4301585429 creator A5032087424 @default.
- W4301585429 creator A5051918272 @default.
- W4301585429 creator A5066470294 @default.
- W4301585429 date "2022-10-05" @default.
- W4301585429 modified "2023-10-17" @default.
- W4301585429 title "GABAA signaling, focal epileptiform synchronization and epileptogenesis" @default.
- W4301585429 cites W1565624927 @default.
- W4301585429 cites W1603732963 @default.
- W4301585429 cites W1623815617 @default.
- W4301585429 cites W1770958704 @default.
- W4301585429 cites W1819857017 @default.
- W4301585429 cites W1828807460 @default.
- W4301585429 cites W1912234705 @default.
- W4301585429 cites W1963710870 @default.
- W4301585429 cites W1963764668 @default.
- W4301585429 cites W1965234912 @default.
- W4301585429 cites W1967861153 @default.
- W4301585429 cites W1970604942 @default.
- W4301585429 cites W1970931021 @default.
- W4301585429 cites W1971778378 @default.
- W4301585429 cites W1971815377 @default.
- W4301585429 cites W1972225310 @default.
- W4301585429 cites W1978929982 @default.
- W4301585429 cites W1982890379 @default.
- W4301585429 cites W1986821858 @default.
- W4301585429 cites W1987293082 @default.
- W4301585429 cites W1987398739 @default.
- W4301585429 cites W1988222024 @default.
- W4301585429 cites W1989710398 @default.
- W4301585429 cites W1996894513 @default.
- W4301585429 cites W1998952799 @default.
- W4301585429 cites W2000135760 @default.
- W4301585429 cites W2000549249 @default.
- W4301585429 cites W2001954021 @default.
- W4301585429 cites W2002889165 @default.
- W4301585429 cites W2003548320 @default.
- W4301585429 cites W2004017387 @default.
- W4301585429 cites W2008421609 @default.
- W4301585429 cites W2009983656 @default.
- W4301585429 cites W2010817672 @default.
- W4301585429 cites W2011137107 @default.
- W4301585429 cites W2012977884 @default.
- W4301585429 cites W2023663290 @default.
- W4301585429 cites W2023871512 @default.
- W4301585429 cites W2024667826 @default.
- W4301585429 cites W2027319774 @default.
- W4301585429 cites W2029598577 @default.
- W4301585429 cites W2031617630 @default.
- W4301585429 cites W2036030776 @default.
- W4301585429 cites W2038969450 @default.
- W4301585429 cites W2040494803 @default.
- W4301585429 cites W2041323061 @default.
- W4301585429 cites W2049312278 @default.
- W4301585429 cites W2050512750 @default.
- W4301585429 cites W2051340527 @default.
- W4301585429 cites W2053168002 @default.
- W4301585429 cites W2056189505 @default.
- W4301585429 cites W2058698189 @default.
- W4301585429 cites W2059658339 @default.
- W4301585429 cites W2059754952 @default.
- W4301585429 cites W2067612400 @default.
- W4301585429 cites W2069586118 @default.
- W4301585429 cites W2074662489 @default.
- W4301585429 cites W2077377885 @default.
- W4301585429 cites W2079164751 @default.
- W4301585429 cites W2080132103 @default.
- W4301585429 cites W2084093942 @default.
- W4301585429 cites W2084712021 @default.
- W4301585429 cites W2086631609 @default.
- W4301585429 cites W2089760277 @default.
- W4301585429 cites W2090243118 @default.
- W4301585429 cites W2092225093 @default.
- W4301585429 cites W2092254652 @default.
- W4301585429 cites W2101604610 @default.
- W4301585429 cites W2104766969 @default.
- W4301585429 cites W2104920115 @default.
- W4301585429 cites W2105003565 @default.
- W4301585429 cites W2105027238 @default.
- W4301585429 cites W2113981430 @default.
- W4301585429 cites W2114091591 @default.
- W4301585429 cites W2120278577 @default.
- W4301585429 cites W2121709831 @default.
- W4301585429 cites W2122300627 @default.
- W4301585429 cites W2129494871 @default.
- W4301585429 cites W2131046634 @default.
- W4301585429 cites W2131077178 @default.
- W4301585429 cites W2132701603 @default.
- W4301585429 cites W2137591123 @default.
- W4301585429 cites W2139755184 @default.
- W4301585429 cites W2141554976 @default.
- W4301585429 cites W2145869886 @default.
- W4301585429 cites W2157002015 @default.
- W4301585429 cites W2161367071 @default.
- W4301585429 cites W2162418003 @default.
- W4301585429 cites W2164493064 @default.