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- W4301586483 abstract "Historically, the gold-standard benchmark for vaccine immunogenicity has been the induction of neutralizing antibodies detectable in the serum of peripheral blood. However, in recent years there has been a new appreciation for the mucosa as an important site for vaccine induced immunity. As a point of first contact, the mucosal tissue represents a major site of immune based detection and restriction of pathogen entry and dissemination. Tissue resident memory T cells (T rm ) are one of the critical cell types involved in this early detection and restriction of mucosal pathogens. Following tissue-specific infection or vaccination, T rm lodge themselves within tissues and can perform rapid sensing and alarm functions to control local re-infections, in an effort that has been defined as important for restriction of a number of respiratory pathogens including influenza and respiratory syncytial virus. Despite this characterized importance, only minor attention has been paid to the importance of T rm as a benchmark for vaccine immunogenicity. The purpose of this review is to highlight the functions of T rm with particular emphasis on respiratory infections, and to suggest the inclusion of T rm elicitation as a benchmark for vaccine immunogenicity in animal models, and where possible, human samples." @default.
- W4301586483 created "2022-10-05" @default.
- W4301586483 creator A5042920740 @default.
- W4301586483 creator A5056006599 @default.
- W4301586483 date "2022-10-04" @default.
- W4301586483 modified "2023-10-14" @default.
- W4301586483 title "Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity" @default.
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- W4301586483 doi "https://doi.org/10.3389/fimmu.2022.1039194" @default.
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