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- W4301586522 abstract "The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple oral diseases. However, the pathogenic mechanism underlying SASP has not yet been fully elucidated. Here, relevant articles on SASP published over the last five years (2017–2022) were retrieved and used for bibliometric analysis, for the first time, to examine SASP composition. More than half of the relevant articles focus on various cytokines (27.5%), growth factors (20.9%), and proteases (20.9%). In addition, lipid metabolites (13.1%) and extracellular vesicles (6.5%) have received increasing attention over the past five years, and have been recognized as novel SASP categories. Based on this, we summarize the evidences demonstrating that SASP plays a pleiotropic role in oral immunity and propose a four-step hypothetical framework for the progression of SASP-related oral pathology—1) oral SASP development, 2) SASP-related oral pathological alterations, 3) pathological changes leading to oral immune homeostasis disruption, and 4) SASP-mediated immune dysregulation escalating oral disease. By targeting specific SASP factors, potential therapies can be developed to treat oral and age-related diseases." @default.
- W4301586522 created "2022-10-05" @default.
- W4301586522 creator A5015195367 @default.
- W4301586522 creator A5019934303 @default.
- W4301586522 creator A5023900879 @default.
- W4301586522 creator A5042059709 @default.
- W4301586522 creator A5062676861 @default.
- W4301586522 creator A5077144422 @default.
- W4301586522 date "2022-10-04" @default.
- W4301586522 modified "2023-10-02" @default.
- W4301586522 title "Senescence-associated secretory phenotype and its impact on oral immune homeostasis" @default.
- W4301586522 cites W1582822824 @default.
- W4301586522 cites W1601771278 @default.
- W4301586522 cites W1639854378 @default.
- W4301586522 cites W1800944583 @default.
- W4301586522 cites W1810441673 @default.
- W4301586522 cites W1910950086 @default.
- W4301586522 cites W1917832294 @default.
- W4301586522 cites W1965498876 @default.
- W4301586522 cites W1978404036 @default.
- W4301586522 cites W1993347579 @default.
- W4301586522 cites W1997680731 @default.
- W4301586522 cites W2004314923 @default.
- W4301586522 cites W2005822229 @default.
- W4301586522 cites W2007452394 @default.
- W4301586522 cites W2015670347 @default.
- W4301586522 cites W2018135697 @default.
- W4301586522 cites W2018321060 @default.
- W4301586522 cites W2019146941 @default.
- W4301586522 cites W2023329633 @default.
- W4301586522 cites W2029127465 @default.
- W4301586522 cites W2030056309 @default.
- W4301586522 cites W2034018042 @default.
- W4301586522 cites W2041892424 @default.
- W4301586522 cites W2046922531 @default.
- W4301586522 cites W2048270768 @default.
- W4301586522 cites W2060018931 @default.
- W4301586522 cites W2070276853 @default.
- W4301586522 cites W2077510301 @default.
- W4301586522 cites W2080232352 @default.
- W4301586522 cites W2091590961 @default.
- W4301586522 cites W2098703322 @default.
- W4301586522 cites W2104849855 @default.
- W4301586522 cites W2106330382 @default.
- W4301586522 cites W2111971681 @default.
- W4301586522 cites W2114982159 @default.
- W4301586522 cites W2116054786 @default.
- W4301586522 cites W2119785660 @default.
- W4301586522 cites W2121200172 @default.
- W4301586522 cites W2127008679 @default.
- W4301586522 cites W2135804517 @default.
- W4301586522 cites W2146902738 @default.
- W4301586522 cites W2147030667 @default.
- W4301586522 cites W2149615029 @default.
- W4301586522 cites W2151257334 @default.
- W4301586522 cites W2154116310 @default.
- W4301586522 cites W2155510706 @default.
- W4301586522 cites W2159055489 @default.
- W4301586522 cites W2161682129 @default.
- W4301586522 cites W2175194582 @default.
- W4301586522 cites W2292535579 @default.
- W4301586522 cites W2342055991 @default.
- W4301586522 cites W2411826498 @default.
- W4301586522 cites W2415383291 @default.
- W4301586522 cites W2460047577 @default.
- W4301586522 cites W2464280382 @default.
- W4301586522 cites W2466285639 @default.
- W4301586522 cites W2471472301 @default.
- W4301586522 cites W2471558537 @default.
- W4301586522 cites W2486734007 @default.
- W4301586522 cites W2505101453 @default.
- W4301586522 cites W2511627766 @default.
- W4301586522 cites W2519576150 @default.
- W4301586522 cites W2530158439 @default.
- W4301586522 cites W2565504617 @default.
- W4301586522 cites W2586342279 @default.
- W4301586522 cites W2594668559 @default.
- W4301586522 cites W2620914886 @default.
- W4301586522 cites W2737657642 @default.
- W4301586522 cites W2748810297 @default.
- W4301586522 cites W2749511637 @default.
- W4301586522 cites W2750509325 @default.
- W4301586522 cites W2779444716 @default.
- W4301586522 cites W2788548733 @default.
- W4301586522 cites W2791147412 @default.
- W4301586522 cites W2793699796 @default.
- W4301586522 cites W2795134170 @default.
- W4301586522 cites W2801089620 @default.
- W4301586522 cites W2805574461 @default.
- W4301586522 cites W2884100091 @default.
- W4301586522 cites W2890430272 @default.
- W4301586522 cites W2901193954 @default.
- W4301586522 cites W2903083130 @default.
- W4301586522 cites W2904348161 @default.
- W4301586522 cites W2907916986 @default.
- W4301586522 cites W2908922892 @default.
- W4301586522 cites W2911642321 @default.
- W4301586522 cites W2946727558 @default.
- W4301586522 cites W2948898093 @default.
- W4301586522 cites W2967864543 @default.