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- W4301603386 abstract "Long-interspersed element 1 (LINE-1) is an autonomous non-LTR retrotransposon. Its replication can cause mutation and rearrangement of host genomic DNA, which may result in serious genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we reported that CCHC-type zinc-finger protein ZCCHC3 can repress LINE-1 retrotransposition, and this activity is closely related to its zinc-finger domain. Further studies show that ZCCHC3 can post-transcriptionally diminish the LINE-1 RNA level. The association of ZCCHC3 with both LINE-1 RNA and ORF1 suggests that ZCCHC3 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstrate collectively that ZCCHC3 contributes to the cellular control of LINE-1 replication." @default.
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- W4301603386 date "2022-10-05" @default.
- W4301603386 modified "2023-09-26" @default.
- W4301603386 title "The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition" @default.
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- W4301603386 doi "https://doi.org/10.3389/fmicb.2022.891852" @default.
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