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- W4301606331 abstract "Electrically excitable cells such as neurons transmit long-distance calcium or electrical signals to regulate their physiological functions. While the molecular underpinnings and down-stream effects of these intercellular communications in excitable cells have been well appreciated, little is known about whether and how non-excitable cancer cells spontaneously initiate and transmit long-distance intercellular signals. Here we report that non-excitable human colon and prostate cancer cells spontaneously initiate and spread intercellular calcium waves, in vitro and ex vivo. Xenograft model studies suggest that these calcium signals promote the growth rate of tumors in mice. Pharmacological studies elucidated that the inositol-trisphosphate-receptor (IP3R)-regulated calcium release from endoplasmic reticulum (ER), which is activated by the Gq-PLC-IP3R pathway, is a major cause for the initiation of spontaneous calcium transients. Further, the spatial-temporal characteristics of calcium dynamics can be tuned by the culture substrates of different mechanical stiffnesses. Our results provide evidence that calcium dynamics enables long-distance functional communication in non-excitable cancer cells and offer the potential to modulate calcium signaling for new cancer therapies." @default.
- W4301606331 created "2022-10-05" @default.
- W4301606331 creator A5001008875 @default.
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- W4301606331 creator A5085737081 @default.
- W4301606331 creator A5088218863 @default.
- W4301606331 date "2022-11-01" @default.
- W4301606331 modified "2023-10-06" @default.
- W4301606331 title "Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth" @default.
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