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- W4301672445 abstract "ABSTRACT We analysed the neurulation movements in the Mexican salamander Ambystoma mexicanum. Embryos were exposed to colchicine or nocodazole prior to neural fold formation. Exposure to these drugs prevented the anterior neural folds from closing. Neurulation however proceeded normally in the posterior regions of the embryo. We were unable to find apically constricted cells in the neural plate of colchicine-blocked neurulae. Only rounded-up neural plate cells were present (semithin sections). This situation was typical in embryos exposed to colchicine prior to neural fold formation. Concentrations of colchicine up to 2 ·5 × 10-3 were not capable of blocking neurulation once the neural folds were formed. The wedge-shaped cells were present in similar numbers to those found in controls. We quantified the cell shape changes in the neural plate and in the epidermis in both controls and drug-arrested embryos. The comparison of these to classes of data shows that epidermal spreading is prevented by colchicine but only slightly affected by nocodazole. Embryos blocked in late neurulation by exposure to these drugs can resume neurulation following neural plate excision in nocodazole but not in colchicine. We conclude from this observation that the epidermis contributes to raising and closing of the neural folds. The presence of neural folds in absence of wedge-shaped cells in the neural plate is also taken as evidence that neurulation is not exclusively driven by forces generated in or acting on the neural plate. Our view on the concerted interplay of various embryonic components is illustrated in a summarizing diagram (Fig. 11)." @default.
- W4301672445 created "2022-10-05" @default.
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- W4301672445 date "1983-04-01" @default.
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- W4301672445 title "Neurulation in the Mexican salamander <i>(Ambystoma mexicanum)</i> : a drug study and cell shape analysis of the epidermis and the neural plate" @default.
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- W4301672445 doi "https://doi.org/10.1242/dev.74.1.275" @default.
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