Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301673693> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4301673693 endingPage "448" @default.
- W4301673693 startingPage "443" @default.
- W4301673693 abstract "THIRTY PATIENTS RECEIVED MITOMYCIN C by constant infusion for 5 consecutive days (16 patients) or for extended periods by an ambulatory infusion pump (Cor-Med model) for 9 to 30 days (14 patients). The short-term 5-day infusions were delivered at dose rates of 2, 3, 4, 5 and 6 mg/m2/d with a cumulative dose of 15–50 mg. The protracted infusions were delivered at dose rates of 0.75–3 mg/m2/d with a cumulative dose of 21.6–65.2 mg. Marrow suppression was dose-limiting and occurred in 5/6 evaluable patients receiving more than 30 mg in the short-term infusion schedule and 8/10 evaluable patients receiving more than 20 mg in the protracted infusion schedule. The characteristics of the marrow suppression are that: a) thrombocytopenia precedes or is observed without concomitant leukopenia and b) the nadir day is delayed (WBC day 42, platelet day 36). Mitomycin C delivered by constant infusion leads to dose-limiting marrow toxicity at 20 to 30 mg cumulative dose depending upon the dose rate and duration of treatment. For short-term 5-day therapy, 3 mg/m2/d and for protracted therapy (up to 30 d) 0.75 mg/m2/d are the recommended dose rates for the constant infusion schedule." @default.
- W4301673693 created "2022-10-05" @default.
- W4301673693 creator A5008718336 @default.
- W4301673693 creator A5026449780 @default.
- W4301673693 creator A5032226272 @default.
- W4301673693 creator A5051379684 @default.
- W4301673693 creator A5058844164 @default.
- W4301673693 creator A5067285726 @default.
- W4301673693 creator A5072333039 @default.
- W4301673693 date "1982-08-01" @default.
- W4301673693 modified "2023-09-27" @default.
- W4301673693 title "Mitomycin C" @default.
- W4301673693 doi "https://doi.org/10.1097/00000421-198208000-00017" @default.
- W4301673693 hasPublicationYear "1982" @default.
- W4301673693 type Work @default.
- W4301673693 citedByCount "7" @default.
- W4301673693 crossrefType "journal-article" @default.
- W4301673693 hasAuthorship W4301673693A5008718336 @default.
- W4301673693 hasAuthorship W4301673693A5026449780 @default.
- W4301673693 hasAuthorship W4301673693A5032226272 @default.
- W4301673693 hasAuthorship W4301673693A5051379684 @default.
- W4301673693 hasAuthorship W4301673693A5058844164 @default.
- W4301673693 hasAuthorship W4301673693A5067285726 @default.
- W4301673693 hasAuthorship W4301673693A5072333039 @default.
- W4301673693 hasConcept C126322002 @default.
- W4301673693 hasConcept C126894567 @default.
- W4301673693 hasConcept C141071460 @default.
- W4301673693 hasConcept C151032500 @default.
- W4301673693 hasConcept C2776694085 @default.
- W4301673693 hasConcept C2779338040 @default.
- W4301673693 hasConcept C2779384505 @default.
- W4301673693 hasConcept C2780873365 @default.
- W4301673693 hasConcept C29730261 @default.
- W4301673693 hasConcept C35785553 @default.
- W4301673693 hasConcept C42219234 @default.
- W4301673693 hasConcept C71924100 @default.
- W4301673693 hasConcept C90924648 @default.
- W4301673693 hasConceptScore W4301673693C126322002 @default.
- W4301673693 hasConceptScore W4301673693C126894567 @default.
- W4301673693 hasConceptScore W4301673693C141071460 @default.
- W4301673693 hasConceptScore W4301673693C151032500 @default.
- W4301673693 hasConceptScore W4301673693C2776694085 @default.
- W4301673693 hasConceptScore W4301673693C2779338040 @default.
- W4301673693 hasConceptScore W4301673693C2779384505 @default.
- W4301673693 hasConceptScore W4301673693C2780873365 @default.
- W4301673693 hasConceptScore W4301673693C29730261 @default.
- W4301673693 hasConceptScore W4301673693C35785553 @default.
- W4301673693 hasConceptScore W4301673693C42219234 @default.
- W4301673693 hasConceptScore W4301673693C71924100 @default.
- W4301673693 hasConceptScore W4301673693C90924648 @default.
- W4301673693 hasIssue "4" @default.
- W4301673693 hasLocation W43016736931 @default.
- W4301673693 hasOpenAccess W4301673693 @default.
- W4301673693 hasPrimaryLocation W43016736931 @default.
- W4301673693 hasRelatedWork W1484554393 @default.
- W4301673693 hasRelatedWork W1967315421 @default.
- W4301673693 hasRelatedWork W1984947670 @default.
- W4301673693 hasRelatedWork W2036782671 @default.
- W4301673693 hasRelatedWork W2094796405 @default.
- W4301673693 hasRelatedWork W2310392076 @default.
- W4301673693 hasRelatedWork W2402942909 @default.
- W4301673693 hasRelatedWork W2425126247 @default.
- W4301673693 hasRelatedWork W3163527107 @default.
- W4301673693 hasRelatedWork W1992449473 @default.
- W4301673693 hasVolume "5" @default.
- W4301673693 isParatext "false" @default.
- W4301673693 isRetracted "false" @default.
- W4301673693 workType "article" @default.