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- W4301712627 abstract "This chapter discusses the achievements of drug development in cholinergic research, 1969–1989. The past two decades have seen a flood of new information on the components of cholinergic systems and the functional relationships among them. The techniques of molecular biology, ultrastructural morphology, radioligand binding, and analytical chemistry have played major roles in these advances and in turn have depended on the availability of specific high-affinity or irreversible ligands, such as drugs. The emphasis on enhancement of cholinergic function that has characterized the past decade will at best yield drugs, which are of temporary and symptomatic benefit. It seems likely that the years to come will provide a better understanding of the processes controlling development, differentiation, maintenance, and repair of cholinergic neurons. This will lead to a new generation of drugs, which modulate these processes. The next 20 years may well see advances in neurochemistry and pharmacology, which will allow presymptomatic diagnosis and even prophylaxis of the progressive degenerative diseases that threaten the present generation." @default.
- W4301712627 created "2022-10-05" @default.
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- W4301712627 date "1990-01-01" @default.
- W4301712627 modified "2023-09-25" @default.
- W4301712627 title "Chapter 47 Achievements in cholinergic research, 1969–1989: drug development" @default.
- W4301712627 doi "https://doi.org/10.1016/s0079-6123(08)60929-2" @default.
- W4301712627 hasPublicationYear "1990" @default.
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