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• W4301773032 abstract "HomeHypertensionVol. 4, No. 3_pt_2Renal prostaglandins and the control of renin release. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBRenal prostaglandins and the control of renin release. R H Freeman, J O Davis, J R Dietz, D Villarreal, A A Seymour and S F Echtenkamp R H FreemanR H Freeman Search for more papers by this author , J O DavisJ O Davis Search for more papers by this author , J R DietzJ R Dietz Search for more papers by this author , D VillarrealD Villarreal Search for more papers by this author , A A SeymourA A Seymour Search for more papers by this author and S F EchtenkampS F Echtenkamp Search for more papers by this author Originally published1 May 1982https://doi.org/10.1161/01.HYP.4.3_Pt_2.106Hypertension. 1982;4:106–112AbstractThis study examines the hypothesis that the renal prostaglandins function as essential mediators in stimulus-secretion coupling for one or more of the basic receptor mechanisms in the control of renin release. Changes in plasma renin activity (PRA) were evaluated in response to suprarenal aortic constriction before and after indomethacin administration in conscious dogs with either a single denervated nonfiltering kidney or with intact filtering kidneys. Suprarenal aortic constriction was adjusted to reduce renal perfusion pressure below the autoregulatory range in both groups of dogs. Inhibition of cyclooxygenase with indomethacin significantly decreased urinary prostaglandin E2 (PGE2) excretion, but indomethacin failed to block or attenuate the increase in PRA in response to a decrease in renal perfusion pressure in either group of dogs. These results fail to support the hypothesis that the renal prostaglandins function as essential mediators of the intrarenal receptor mechanisms for renin release which are activated by a decrease in renal perfusion pressure below the autoregulatory range. eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited BySchweda F, Segerer F, Castrop H, Schnermann J and Kurtz A (2005) Blood Pressure–Dependent Inhibition of Renin Secretion Requires A1 Adenosine Receptors, Hypertension, 46:4, (780-786), Online publication date: 1-Oct-2005. May 1982Vol 4, Issue 3_pt_2 Advertisement Article InformationMetrics Copyright © 1982 by American Heart Associationhttps://doi.org/10.1161/01.HYP.4.3_Pt_2.106PMID: 7040235 Originally publishedMay 1, 1982 PDF download Advertisement" @default.
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• W4301773032 title "Renal prostaglandins and the control of renin release." @default.
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