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- W4301874340 abstract "The lifetimes of non-covalent A:a knob-hole bonds in fibrin probed with the optical trap-based force-clamp first increases (catch bonds) and then decreases (slip bonds) with increasing tensile force. Molecular modeling of catch-to-slip transition using the atomic structure of the A:a complex reveals that the movable flap serves as tension-dependent molecular switch. Flap dissociation from the regulatory B-domain in $gamma$-nodule and translocation from the periphery to knob `A' triggers the hole `a' closure and interface remodeling, which results in the increased binding affinity and prolonged bond lifetimes. Fluctuating bottleneck theory is developed to understand the catch-to-slip transition in terms of the interface stiffness $kappa =$ 15.7 pN nm $^{-1}$, interface size fluctuations 0.7-2.7 nm, knob `A' escape rate constant $k_0 =$ 0.11 nm$^2$ s$^{-1}$, and transition distance for dissociation $sigma_y =$ 0.25 nm. Strengthening of the A:a knob-hole bonds under small tension might favor formation and reinforcement of nascent fibrin clots under hydrodynamic shear." @default.
- W4301874340 created "2022-10-05" @default.
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- W4301874340 date "2017-09-17" @default.
- W4301874340 modified "2023-10-17" @default.
- W4301874340 title "Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin" @default.
- W4301874340 doi "https://doi.org/10.48550/arxiv.1709.05727" @default.
- W4301874340 hasPublicationYear "2017" @default.
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