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- W4302011911 endingPage "1834" @default.
- W4302011911 startingPage "1823" @default.
- W4302011911 abstract "Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome-and the drugs used to treat it-remain important causes of patient morbidity. Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, diseases that primarily affect the podocytes. In spite of decades of research, the underlying causes of both diseases remain incompletely understood. There is, however, a large body of observational and experimental data linking the immune system with both minimal change disease and FSGS, including associations with systemic infections and hematologic malignancies. Perhaps most compellingly, many different immunomodulatory drugs are effective for treating idiopathic nephrotic syndrome, including biologic agents that have well-defined immune targets. In fact, the unexpected efficacy of targeted therapeutic agents has provided important new insights into the pathogenesis of these diseases. Given the large number of drugs that are available to deplete or block specific cells and molecules within the immune system, a better understanding of the immunologic causes of idiopathic nephrotic syndrome may lead to better diagnostic and therapeutic approaches." @default.
- W4302011911 created "2022-10-06" @default.
- W4302011911 creator A5060385446 @default.
- W4302011911 creator A5079294069 @default.
- W4302011911 date "2022-12-01" @default.
- W4302011911 modified "2023-09-30" @default.
- W4302011911 title "The Immune System and Idiopathic Nephrotic Syndrome" @default.
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