FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302012011> ?p ?o ?g. }

• W4302012011 endingPage "e0274814" @default.
• W4302012011 startingPage "e0274814" @default.
• W4302012011 abstract "Mesenchymal stem cells (MSCs) have seen an elevated use in clinical works like regenerative medicine. Its potential therapeutic properties increases when used in tandem with complementary agents like bio-based materials. Therefore, the present study is the first to investigate the cytotoxicity of a highly valued medicinal plant, Moringa oleifera, on human Wharton's Jelly mesenchymal stem cells (hWJMSCs) and its effects on the cells' gene expression when used as a pre-treatment agent in vitro. M. oleifera leaves (MOL) were dried and subjected to UHPLC-QTOF/MS analysis, revealing several major compounds like apigenin, kaempferol, and quercetin in the MOL, with various biological activities like antioxidant and anti-cancer properties. We then treated the hWJMSCs with MOL and noticed a dose-dependant inhibition on the cells' proliferation. RNA-sequencing was performed to explain the possible mechanism of action and revealed genes like PPP1R1C, SULT2B1, CDKN1A, mir-154 and CCNB1, whose expression patterns were closely associated with the negative cell cycle regulation and cell cycle arrest process. This is also evident from gene set enrichment analysis where the GO and KEGG terms for down-regulated pathways were closely related to the cell cycle regulation. The Ingenuity pathway analysis (IPA) software further predicted the significant activation of (p < 0.05, z-score > 2) of the G2/M DNA damage checkpoint regulation pathway. The present study suggests that MOL exhibits an antiproliferative effect on hWJMSCs via cell cycle arrest and apoptotic pathways. We believe that this study provides an important baseline reference for future works involving MOL's potential to accompany MSCs for clinical works. Future works can take advantage of the cell's strong anti-cancer gene expression found in this study, and evaluate our MOL treatment on various cancer cell lines." @default.
• W4302012011 created "2022-10-06" @default.
• W4302012011 creator A5001781199 @default.
• W4302012011 creator A5013995375 @default.
• W4302012011 creator A5030686068 @default.
• W4302012011 creator A5036294359 @default.
• W4302012011 creator A5070112018 @default.
• W4302012011 creator A5080152607 @default.
• W4302012011 creator A5090737963 @default.
• W4302012011 date "2022-10-05" @default.
• W4302012011 modified "2023-10-14" @default.
• W4302012011 title "Antiproliferative effects of dried Moringa oleifera leaf extract on human Wharton’s Jelly mesenchymal stem cells" @default.
• W4302012011 cites W1554037372 @default.
• W4302012011 cites W1940860699 @default.
• W4302012011 cites W1981738496 @default.
• W4302012011 cites W1984168218 @default.
• W4302012011 cites W1986490557 @default.
• W4302012011 cites W2002661196 @default.
• W4302012011 cites W2025371271 @default.
• W4302012011 cites W2036329051 @default.
• W4302012011 cites W2039539873 @default.
• W4302012011 cites W2046277450 @default.
• W4302012011 cites W2060747244 @default.
• W4302012011 cites W2063529247 @default.
• W4302012011 cites W2072268939 @default.
• W4302012011 cites W2077391866 @default.
• W4302012011 cites W2082882104 @default.
• W4302012011 cites W2086096314 @default.
• W4302012011 cites W2117692326 @default.
• W4302012011 cites W2121787561 @default.
• W4302012011 cites W2125253773 @default.
• W4302012011 cites W2161145604 @default.
• W4302012011 cites W2162143298 @default.
• W4302012011 cites W2217702706 @default.
• W4302012011 cites W2283292195 @default.
• W4302012011 cites W2333802498 @default.
• W4302012011 cites W2333837067 @default.
• W4302012011 cites W2397575385 @default.
• W4302012011 cites W2416643232 @default.
• W4302012011 cites W2471809489 @default.
• W4302012011 cites W2480082790 @default.
• W4302012011 cites W2482469398 @default.
• W4302012011 cites W2540599737 @default.
• W4302012011 cites W2555727071 @default.
• W4302012011 cites W2587436688 @default.
• W4302012011 cites W2620980935 @default.
• W4302012011 cites W2625029096 @default.
• W4302012011 cites W2625241981 @default.
• W4302012011 cites W2728835156 @default.
• W4302012011 cites W2756938630 @default.
• W4302012011 cites W2772966448 @default.
• W4302012011 cites W2788691422 @default.
• W4302012011 cites W2791175240 @default.
• W4302012011 cites W2799497776 @default.
• W4302012011 cites W2802729107 @default.
• W4302012011 cites W2804281184 @default.
• W4302012011 cites W2805132328 @default.
• W4302012011 cites W2883031273 @default.
• W4302012011 cites W2884181644 @default.
• W4302012011 cites W2894735978 @default.
• W4302012011 cites W2918843079 @default.
• W4302012011 cites W2919285091 @default.
• W4302012011 cites W2927600111 @default.
• W4302012011 cites W2936589723 @default.
• W4302012011 cites W2938112561 @default.
• W4302012011 cites W2946490342 @default.
• W4302012011 cites W2951902079 @default.
• W4302012011 cites W2959362907 @default.
• W4302012011 cites W2967057123 @default.
• W4302012011 cites W2967937728 @default.
• W4302012011 cites W2969845879 @default.
• W4302012011 cites W2970600215 @default.
• W4302012011 cites W2971546847 @default.
• W4302012011 cites W2971896963 @default.
• W4302012011 cites W2973883332 @default.
• W4302012011 cites W2980517636 @default.
• W4302012011 cites W2991413554 @default.
• W4302012011 cites W2992974753 @default.
• W4302012011 cites W3004934227 @default.
• W4302012011 cites W3005606399 @default.
• W4302012011 cites W3009354525 @default.
• W4302012011 cites W3011220214 @default.
• W4302012011 cites W3019552881 @default.
• W4302012011 cites W3035253480 @default.
• W4302012011 cites W3037767949 @default.
• W4302012011 cites W3047581310 @default.
• W4302012011 cites W3047669586 @default.
• W4302012011 cites W3048366133 @default.
• W4302012011 cites W3049072724 @default.
• W4302012011 cites W3082971081 @default.
• W4302012011 cites W3084755543 @default.
• W4302012011 cites W3092560126 @default.
• W4302012011 cites W3097309053 @default.
• W4302012011 cites W3107789866 @default.
• W4302012011 cites W3130190796 @default.
• W4302012011 cites W3149491847 @default.
• W4302012011 cites W3159928911 @default.
• W4302012011 cites W3163123398 @default.

• next