FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302014146> ?p ?o ?g. }

• W4302014146 abstract "PURPOSE Adverse events (AEs) on Children's Oncology Group (COG) trials are manually ascertained using Common Terminology Criteria for Adverse Events. Despite significant effort, we previously demonstrated that COG typhlitis reporting sensitivity was only 37% when compared with gold standard physician chart abstraction. This study tested an automated typhlitis identification algorithm using electronic health record data. METHODS Electronic health record data from children with leukemia age 0-22 years treated at a single institution from 2006 to 2019 were included. Patients were divided into derivation and validation cohorts. Rigorous chart abstraction of validation cohort patients established a gold standard AE data set. We created an automated algorithm to identify typhlitis matching Common Terminology Criteria for Adverse Events v5 that included antibiotics, neutropenia, and non-negated mention of typhlitis in a note. We iteratively refined the algorithm using the derivation cohort and then applied the algorithm to the validation cohort; performance was compared with the gold standard. For patients on trial AAML1031, COG AE report performance was compared with the gold standard. RESULTS The derivation cohort included 337 patients. The validation cohort included 270 patients (961 courses). Chart abstraction identified 16 courses with typhlitis. The algorithm identified 37 courses with typhlitis; 13 were true positives (sensitivity 81.3%, positive predictive value 35.1%). For patients on AAML1031, chart abstraction identified nine courses with typhlitis, and COG reporting correctly identified 4 (sensitivity 44.4%, positive predictive value 100.0%). CONCLUSION The automated algorithm identified true cases of typhlitis with higher sensitivity than COG reporting. The algorithm identified false positives but reduced the number of courses needing manual review by 96% (961 to 37) by detecting potential typhlitis. This algorithm could provide a useful screening tool to reduce manual effort required for typhlitis AE reporting." @default.
• W4302014146 created "2022-10-06" @default.
• W4302014146 creator A5011994567 @default.
• W4302014146 creator A5017202683 @default.
• W4302014146 creator A5021003209 @default.
• W4302014146 creator A5036058743 @default.
• W4302014146 creator A5036356438 @default.
• W4302014146 creator A5037359116 @default.
• W4302014146 creator A5039413618 @default.
• W4302014146 creator A5047113971 @default.
• W4302014146 creator A5053822814 @default.
• W4302014146 creator A5059022495 @default.
• W4302014146 creator A5066861312 @default.
• W4302014146 creator A5083808934 @default.
• W4302014146 creator A5090029894 @default.
• W4302014146 date "2022-09-01" @default.
• W4302014146 modified "2023-10-16" @default.
• W4302014146 title "Automated Ascertainment of Typhlitis From the Electronic Health Record" @default.
• W4302014146 cites W2014202038 @default.
• W4302014146 cites W2057753341 @default.
• W4302014146 cites W2083958971 @default.
• W4302014146 cites W2119896493 @default.
• W4302014146 cites W2165690041 @default.
• W4302014146 cites W2166213950 @default.
• W4302014146 cites W2169923083 @default.
• W4302014146 cites W2285761451 @default.
• W4302014146 cites W2380567717 @default.
• W4302014146 cites W2584243050 @default.
• W4302014146 cites W2692859861 @default.
• W4302014146 cites W3004873674 @default.
• W4302014146 cites W3153489706 @default.
• W4302014146 cites W3161622679 @default.
• W4302014146 cites W3193276240 @default.
• W4302014146 cites W4210742359 @default.
• W4302014146 cites W4225313196 @default.
• W4302014146 cites W4251270351 @default.
• W4302014146 doi "https://doi.org/10.1200/cci.22.00081" @default.
• W4302014146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36198128" @default.
• W4302014146 hasPublicationYear "2022" @default.
• W4302014146 type Work @default.
• W4302014146 citedByCount "1" @default.
• W4302014146 crossrefType "journal-article" @default.
• W4302014146 hasAuthorship W4302014146A5011994567 @default.
• W4302014146 hasAuthorship W4302014146A5017202683 @default.
• W4302014146 hasAuthorship W4302014146A5021003209 @default.
• W4302014146 hasAuthorship W4302014146A5036058743 @default.
• W4302014146 hasAuthorship W4302014146A5036356438 @default.
• W4302014146 hasAuthorship W4302014146A5037359116 @default.
• W4302014146 hasAuthorship W4302014146A5039413618 @default.
• W4302014146 hasAuthorship W4302014146A5047113971 @default.
• W4302014146 hasAuthorship W4302014146A5053822814 @default.
• W4302014146 hasAuthorship W4302014146A5059022495 @default.
• W4302014146 hasAuthorship W4302014146A5066861312 @default.
• W4302014146 hasAuthorship W4302014146A5083808934 @default.
• W4302014146 hasAuthorship W4302014146A5090029894 @default.
• W4302014146 hasConcept C105795698 @default.
• W4302014146 hasConcept C11413529 @default.
• W4302014146 hasConcept C126322002 @default.
• W4302014146 hasConcept C154945302 @default.
• W4302014146 hasConcept C190812933 @default.
• W4302014146 hasConcept C197934379 @default.
• W4302014146 hasConcept C2777793932 @default.
• W4302014146 hasConcept C33923547 @default.
• W4302014146 hasConcept C40993552 @default.
• W4302014146 hasConcept C41008148 @default.
• W4302014146 hasConcept C4661277 @default.
• W4302014146 hasConcept C71924100 @default.
• W4302014146 hasConcept C72563966 @default.
• W4302014146 hasConceptScore W4302014146C105795698 @default.
• W4302014146 hasConceptScore W4302014146C11413529 @default.
• W4302014146 hasConceptScore W4302014146C126322002 @default.
• W4302014146 hasConceptScore W4302014146C154945302 @default.
• W4302014146 hasConceptScore W4302014146C190812933 @default.
• W4302014146 hasConceptScore W4302014146C197934379 @default.
• W4302014146 hasConceptScore W4302014146C2777793932 @default.
• W4302014146 hasConceptScore W4302014146C33923547 @default.
• W4302014146 hasConceptScore W4302014146C40993552 @default.
• W4302014146 hasConceptScore W4302014146C41008148 @default.
• W4302014146 hasConceptScore W4302014146C4661277 @default.
• W4302014146 hasConceptScore W4302014146C71924100 @default.
• W4302014146 hasConceptScore W4302014146C72563966 @default.
• W4302014146 hasIssue "6" @default.
• W4302014146 hasLocation W43020141461 @default.
• W4302014146 hasLocation W43020141462 @default.
• W4302014146 hasOpenAccess W4302014146 @default.
• W4302014146 hasPrimaryLocation W43020141461 @default.
• W4302014146 hasRelatedWork W2137935439 @default.
• W4302014146 hasRelatedWork W2299753147 @default.
• W4302014146 hasRelatedWork W2792278937 @default.
• W4302014146 hasRelatedWork W2898543788 @default.
• W4302014146 hasRelatedWork W3007985759 @default.
• W4302014146 hasRelatedWork W3011133548 @default.
• W4302014146 hasRelatedWork W4281261911 @default.
• W4302014146 hasRelatedWork W4281949835 @default.
• W4302014146 hasRelatedWork W4311023586 @default.
• W4302014146 hasRelatedWork W4383619592 @default.
• W4302014146 isParatext "false" @default.
• W4302014146 isRetracted "false" @default.
• W4302014146 workType "article" @default.