FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302023756> ?p ?o ?g. }

• W4302023756 endingPage "712" @default.
• W4302023756 startingPage "705" @default.
• W4302023756 abstract "One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their testing on a relevant animal model. The laboratory mouse, with well-studied immunology, is the preferred mammalian model in experimental medicine. However, mice are not susceptible to infection with SARS-CoV-2 due to the lack of human angiotensin-converting enzyme (hACE2), which is the cell receptor of SARS-CoV-2 and necessary for the entry of the virus into the cell. In present work, it was shown that intranasal administration of the adeno-associated vectors AAV9 and AAV-DJ encoding the hACE2 provided a high level of expression of ACE2 gene in the lungs of mice. In contrast, the introduction of the AAV6 vector led to a low level ACE2 expression. Infection with SARS-CoV-2 of mice expressing hACE2 in the lungs led to virus replication and development of bronchopneumonia on the 7th day after infection. Thus, a simple method for delivering the human ACE2 gene to mouse lungs by intranasal administration of the AAV vector has been proposed. This approach enabled rapid generation of mouse model for studying coronavirus infection." @default.
• W4302023756 created "2022-10-06" @default.
• W4302023756 creator A5003967319 @default.
• W4302023756 creator A5004889419 @default.
• W4302023756 creator A5013053131 @default.
• W4302023756 creator A5021084276 @default.
• W4302023756 creator A5023793164 @default.
• W4302023756 creator A5024231890 @default.
• W4302023756 creator A5035299485 @default.
• W4302023756 creator A5047917881 @default.
• W4302023756 creator A5055517859 @default.
• W4302023756 creator A5068037862 @default.
• W4302023756 creator A5070901028 @default.
• W4302023756 creator A5073834735 @default.
• W4302023756 creator A5088304182 @default.
• W4302023756 date "2022-10-01" @default.
• W4302023756 modified "2023-10-15" @default.
• W4302023756 title "Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2" @default.
• W4302023756 cites W1981765089 @default.
• W4302023756 cites W1990559406 @default.
• W4302023756 cites W2474614962 @default.
• W4302023756 cites W2616358787 @default.
• W4302023756 cites W2903852220 @default.
• W4302023756 cites W2973390883 @default.
• W4302023756 cites W3033015248 @default.
• W4302023756 cites W3033950875 @default.
• W4302023756 cites W3046988613 @default.
• W4302023756 cites W3047003416 @default.
• W4302023756 cites W3080378920 @default.
• W4302023756 cites W3188108815 @default.
• W4302023756 cites W4200194366 @default.
• W4302023756 doi "https://doi.org/10.1134/s0026893322050065" @default.
• W4302023756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36217340" @default.
• W4302023756 hasPublicationYear "2022" @default.
• W4302023756 type Work @default.
• W4302023756 citedByCount "1" @default.
• W4302023756 countsByYear W43020237562023 @default.
• W4302023756 crossrefType "journal-article" @default.
• W4302023756 hasAuthorship W4302023756A5003967319 @default.
• W4302023756 hasAuthorship W4302023756A5004889419 @default.
• W4302023756 hasAuthorship W4302023756A5013053131 @default.
• W4302023756 hasAuthorship W4302023756A5021084276 @default.
• W4302023756 hasAuthorship W4302023756A5023793164 @default.
• W4302023756 hasAuthorship W4302023756A5024231890 @default.
• W4302023756 hasAuthorship W4302023756A5035299485 @default.
• W4302023756 hasAuthorship W4302023756A5047917881 @default.
• W4302023756 hasAuthorship W4302023756A5055517859 @default.
• W4302023756 hasAuthorship W4302023756A5068037862 @default.
• W4302023756 hasAuthorship W4302023756A5070901028 @default.
• W4302023756 hasAuthorship W4302023756A5073834735 @default.
• W4302023756 hasAuthorship W4302023756A5088304182 @default.
• W4302023756 hasBestOaLocation W43020237561 @default.
• W4302023756 hasConcept C104317684 @default.
• W4302023756 hasConcept C111599444 @default.
• W4302023756 hasConcept C135983454 @default.
• W4302023756 hasConcept C142724271 @default.
• W4302023756 hasConcept C159047783 @default.
• W4302023756 hasConcept C203014093 @default.
• W4302023756 hasConcept C2522874641 @default.
• W4302023756 hasConcept C2775946041 @default.
• W4302023756 hasConcept C2779134260 @default.
• W4302023756 hasConcept C3008058167 @default.
• W4302023756 hasConcept C40767141 @default.
• W4302023756 hasConcept C524204448 @default.
• W4302023756 hasConcept C55493867 @default.
• W4302023756 hasConcept C71924100 @default.
• W4302023756 hasConcept C85663871 @default.
• W4302023756 hasConcept C86803240 @default.
• W4302023756 hasConcept C92087593 @default.
• W4302023756 hasConceptScore W4302023756C104317684 @default.
• W4302023756 hasConceptScore W4302023756C111599444 @default.
• W4302023756 hasConceptScore W4302023756C135983454 @default.
• W4302023756 hasConceptScore W4302023756C142724271 @default.
• W4302023756 hasConceptScore W4302023756C159047783 @default.
• W4302023756 hasConceptScore W4302023756C203014093 @default.
• W4302023756 hasConceptScore W4302023756C2522874641 @default.
• W4302023756 hasConceptScore W4302023756C2775946041 @default.
• W4302023756 hasConceptScore W4302023756C2779134260 @default.
• W4302023756 hasConceptScore W4302023756C3008058167 @default.
• W4302023756 hasConceptScore W4302023756C40767141 @default.
• W4302023756 hasConceptScore W4302023756C524204448 @default.
• W4302023756 hasConceptScore W4302023756C55493867 @default.
• W4302023756 hasConceptScore W4302023756C71924100 @default.
• W4302023756 hasConceptScore W4302023756C85663871 @default.
• W4302023756 hasConceptScore W4302023756C86803240 @default.
• W4302023756 hasConceptScore W4302023756C92087593 @default.
• W4302023756 hasIssue "5" @default.
• W4302023756 hasLocation W43020237561 @default.
• W4302023756 hasLocation W43020237562 @default.
• W4302023756 hasLocation W43020237563 @default.
• W4302023756 hasOpenAccess W4302023756 @default.
• W4302023756 hasPrimaryLocation W43020237561 @default.
• W4302023756 hasRelatedWork W1587611090 @default.
• W4302023756 hasRelatedWork W1602083480 @default.
• W4302023756 hasRelatedWork W1996617040 @default.
• W4302023756 hasRelatedWork W2054739272 @default.
• W4302023756 hasRelatedWork W2079987784 @default.
• W4302023756 hasRelatedWork W2144336433 @default.

• next