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• W4302024645 endingPage "108699" @default.
• W4302024645 startingPage "108699" @default.
• W4302024645 abstract "Substrates with basic structures similar to those of living tissues are useful as cellular scaffolds for the preparation of biocompatible and innocuous materials. In this study, a hydrogel matrix was prepared by introducing a functional group capable of forming crosslinks between natural polymers to create a basis for preparing a microenvironment favorable for cell adaptation. The modified dextran hydrogel polymer was designed to mimic the conditions of the extracellular matrix (ECM) as a scaffold. The precursors of the target hydrogel were synthesized using condensation with a stepwise procedure. A delicate hydrogel based on modified dextran was obtained via photo-crosslinking under room temperature at UV-254 nm. The biocompatibility of this hydrogel was verified using green fluorescence images acquired by incubating a cell line. The characteristics of the hydrogel were verified using proton nuclear magnetic resonance (1H NMR), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD) analysis, and electrostatic spinning. The crosslinked structure and biocompatibility of the modified hydrogel were confirmed using instrumental analyses and a promising cell culture. Using TGA, the weight losses of precursor and hydrogel were determined to be 90.96% and 39.2%, respectively, up to 600 °C. The diameters of the nanofibers, fabricated via electrospinning, were measured to range from 200 to 500 nm." @default.
• W4302024645 created "2022-10-06" @default.
• W4302024645 creator A5012468961 @default.
• W4302024645 creator A5022775284 @default.
• W4302024645 creator A5059224321 @default.
• W4302024645 date "2022-12-01" @default.
• W4302024645 modified "2023-09-28" @default.
• W4302024645 title "Fabrication of innocuous hydrogel scaffolds based on modified dextran for biotissues" @default.
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• W4302024645 doi "https://doi.org/10.1016/j.carres.2022.108699" @default.
• W4302024645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36215933" @default.
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