Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302027605> ?p ?o ?g. }
- W4302027605 abstract "Epidemiological literature indicates that women are less susceptible to type II diabetes (T2D) than males. The general consensus is that estrogen is protective, whereas its deficiency in post-menopause is associated with adiposity and impaired insulin sensitivity. However, epidemiological data suggests that males are more prone to developing T2D, and at a lower BMI, compared to females during post-menopausal years; suggesting that another factor, other than estrogen, protects females. We proposed to determine if adiponectin (APN) serves as this protective factor. An initial experiment was performed in which gonadally intact male and female mice were fed either a purified low-fat diet (LFD) or high-fat diet (HFD) (40% kcals from fat) for 16 weeks. An additional group of HFD ovariectomy (OVX) mice were included to assess estrogen deficiency's impact on obesity. Body composition, adipose tissue inflammation, ectopic lipid accumulation as well as glucose metabolism and insulin resistance were assessed. In corroboration with previous data, estrogen deficiency (OVX) exacerbated HFD-induced obesity in female mice. However, despite a higher body fat percentage and a similar degree of hepatic and skeletal muscle lipid accumulation, female OVX HFD-fed mice exhibited enhanced insulin sensitivity relative to HFD-fed males. Therefore, a subsequent HFD experiment was performed utilizing male and female (both gonadally intact and OVX) APN deficient mice (APN-/-) and wildtype littermates to determine if APN is the factor which protects OVX females from the similar degree of metabolic dysfunction as males in the setting of obesity. Indirect calorimetry was used to determine observed phenotype differences. APN deficiency limited adiposity and mitigated HFD-induced insulin resistance and adipose tissue inflammation in gonadally intact male and female, but not in OVX mice. Using indirect calorimetry, we uncovered that slight, but non-statistically significant differences in food intake and energy expenditure leading to a net difference in energy balance likely explain the reduced body weight exhibited by male APN-deficient mice. In conclusion, congenital APN deficiency is protective against obesity development in gonadally intact mice, however, in the setting of estrogen deficiency (OVX) this is not true. These findings suggest that gonadal status dictates the protective effects of congenital APN deficiency in the setting of HFD-induced obesity." @default.
- W4302027605 created "2022-10-06" @default.
- W4302027605 creator A5025336530 @default.
- W4302027605 creator A5034533169 @default.
- W4302027605 creator A5043015774 @default.
- W4302027605 creator A5051535531 @default.
- W4302027605 creator A5061239650 @default.
- W4302027605 creator A5075967826 @default.
- W4302027605 creator A5076669753 @default.
- W4302027605 creator A5086023704 @default.
- W4302027605 creator A5088834829 @default.
- W4302027605 date "2022-10-05" @default.
- W4302027605 modified "2023-10-15" @default.
- W4302027605 title "Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice" @default.
- W4302027605 cites W1194331047 @default.
- W4302027605 cites W1577577364 @default.
- W4302027605 cites W1967499636 @default.
- W4302027605 cites W1983829521 @default.
- W4302027605 cites W1987786598 @default.
- W4302027605 cites W1992439380 @default.
- W4302027605 cites W2010714663 @default.
- W4302027605 cites W2012273409 @default.
- W4302027605 cites W2018256248 @default.
- W4302027605 cites W2019499862 @default.
- W4302027605 cites W2022310925 @default.
- W4302027605 cites W2022318388 @default.
- W4302027605 cites W2024045979 @default.
- W4302027605 cites W2030604230 @default.
- W4302027605 cites W2040319473 @default.
- W4302027605 cites W2043419594 @default.
- W4302027605 cites W2043439822 @default.
- W4302027605 cites W2049965571 @default.
- W4302027605 cites W2058288946 @default.
- W4302027605 cites W2072137305 @default.
- W4302027605 cites W2079516818 @default.
- W4302027605 cites W2102820875 @default.
- W4302027605 cites W2112417193 @default.
- W4302027605 cites W2113340545 @default.
- W4302027605 cites W2114001485 @default.
- W4302027605 cites W2114616866 @default.
- W4302027605 cites W2120506984 @default.
- W4302027605 cites W2122137486 @default.
- W4302027605 cites W2131503581 @default.
- W4302027605 cites W2139825622 @default.
- W4302027605 cites W2152779889 @default.
- W4302027605 cites W2155658630 @default.
- W4302027605 cites W2156260257 @default.
- W4302027605 cites W2156401392 @default.
- W4302027605 cites W2156831368 @default.
- W4302027605 cites W2159278731 @default.
- W4302027605 cites W2166280318 @default.
- W4302027605 cites W2199056716 @default.
- W4302027605 cites W2303037955 @default.
- W4302027605 cites W2316354990 @default.
- W4302027605 cites W2398046043 @default.
- W4302027605 cites W2521306464 @default.
- W4302027605 cites W2566104016 @default.
- W4302027605 cites W2574600628 @default.
- W4302027605 cites W2619938137 @default.
- W4302027605 cites W2757213160 @default.
- W4302027605 cites W2763922502 @default.
- W4302027605 cites W2773144215 @default.
- W4302027605 cites W2778242679 @default.
- W4302027605 cites W2886865853 @default.
- W4302027605 cites W2906546146 @default.
- W4302027605 cites W2950484331 @default.
- W4302027605 cites W3082764070 @default.
- W4302027605 cites W3089729196 @default.
- W4302027605 cites W3111988148 @default.
- W4302027605 cites W3157889036 @default.
- W4302027605 cites W3169929588 @default.
- W4302027605 cites W3170199623 @default.
- W4302027605 cites W3173033044 @default.
- W4302027605 cites W4200437424 @default.
- W4302027605 doi "https://doi.org/10.1038/s41598-022-21228-x" @default.
- W4302027605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36198723" @default.
- W4302027605 hasPublicationYear "2022" @default.
- W4302027605 type Work @default.
- W4302027605 citedByCount "2" @default.
- W4302027605 countsByYear W43020276052023 @default.
- W4302027605 crossrefType "journal-article" @default.
- W4302027605 hasAuthorship W4302027605A5025336530 @default.
- W4302027605 hasAuthorship W4302027605A5034533169 @default.
- W4302027605 hasAuthorship W4302027605A5043015774 @default.
- W4302027605 hasAuthorship W4302027605A5051535531 @default.
- W4302027605 hasAuthorship W4302027605A5061239650 @default.
- W4302027605 hasAuthorship W4302027605A5075967826 @default.
- W4302027605 hasAuthorship W4302027605A5076669753 @default.
- W4302027605 hasAuthorship W4302027605A5086023704 @default.
- W4302027605 hasAuthorship W4302027605A5088834829 @default.
- W4302027605 hasBestOaLocation W43020276051 @default.
- W4302027605 hasConcept C126322002 @default.
- W4302027605 hasConcept C134018914 @default.
- W4302027605 hasConcept C171089720 @default.
- W4302027605 hasConcept C2776782570 @default.
- W4302027605 hasConcept C2777164284 @default.
- W4302027605 hasConcept C2777180221 @default.
- W4302027605 hasConcept C2777391703 @default.
- W4302027605 hasConcept C2778562196 @default.
- W4302027605 hasConcept C511355011 @default.