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• W4302044462 abstract "Although diltiazem has been shown to alleviate vasospastic angina pectoris, its effect on exercise-inducible chronic stable angina has not been objectively studied. Accordingly, the effect of diltiazem was studied in this condition with a placebo controlled double-blind randomized cross-over protocol at three dose levels (120, 180 and 240 mg/day) during graded treadmill exercise. Three end-points were evaluated: 1) time to onset of angina or fatigue if angina were eliminated; 2) time to 1 mm ST segment depression or fatigue if ST depression were eliminated; and 3) time to termination of exercise (2+ angina or fatigue). All end-points were prolonged at all dose levels. At the highest dose of 240 mg/day, time to onset angina or termination was prolonged from a placebo time of 8.0 ± 0.9 to 9.8 ± 0.9 minutes (p = <.001); time to ST depression or termination was prolonged from 7.8± 0.9 to 9.1 ± 0.8 minutes (p = .007); and time to termination was prolonged from 9.9 ± 0.9 to 10.8 ± 0.8 minutes (p = .02). Although diltiazem has been shown to alleviate vasospastic angina pectoris, its effect on exercise-inducible chronic stable angina has not been objectively studied. Accordingly, the effect of diltiazem was studied in this condition with a placebo controlled double-blind randomized cross-over protocol at three dose levels (120, 180 and 240 mg/day) during graded treadmill exercise. Three end-points were evaluated: 1) time to onset of angina or fatigue if angina were eliminated; 2) time to 1 mm ST segment depression or fatigue if ST depression were eliminated; and 3) time to termination of exercise (2+ angina or fatigue). All end-points were prolonged at all dose levels. At the highest dose of 240 mg/day, time to onset angina or termination was prolonged from a placebo time of 8.0 ± 0.9 to 9.8 ± 0.9 minutes (p = <.001); time to ST depression or termination was prolonged from 7.8± 0.9 to 9.1 ± 0.8 minutes (p = .007); and time to termination was prolonged from 9.9 ± 0.9 to 10.8 ± 0.8 minutes (p = .02)." @default.
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• W4302044462 date "1980-07-01" @default.
• W4302044462 modified "2023-10-05" @default.
• W4302044462 title "The Treatment of Exercise-Inducible Chronic Stable Angina with Diltiazem" @default.
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• W4302044462 doi "https://doi.org/10.1378/chest.78.1_supplement.234" @default.
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