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- W4302275737 abstract "In animals with germ plasm, specification of the germline involves 'germ granules', cytoplasmic condensates that enrich maternal transcripts in the germline founder cells. In Caenorhabditis elegans embryos, P granules enrich maternal transcripts, but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, 'germline P-bodies' contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically-disordered proteins MEG-1 and MEG-2 and the TIS11-family RNA-binding protein POS-1. Embryos lacking meg-1 and meg-2 do not stabilize P-body components, misregulate POS-1 targets, mis-specify the germline founder cell and do not develop a germline. Our findings suggest that specification of the germ line involves at least two distinct condensates that independently enrich and regulate maternal mRNAs in the germline founder cells. This article has an associated 'The people behind the papers' interview." @default.
- W4302275737 created "2022-10-06" @default.
- W4302275737 creator A5048990338 @default.
- W4302275737 creator A5063827423 @default.
- W4302275737 date "2022-11-01" @default.
- W4302275737 modified "2023-10-14" @default.
- W4302275737 title "Specialized germline P-bodies are required to specify germ cell fate in <i>Caenorhabditis elegans</i> embryos" @default.
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- W4302275737 cites W1966150502 @default.
- W4302275737 cites W1974658471 @default.
- W4302275737 cites W1978942137 @default.
- W4302275737 cites W1979819446 @default.
- W4302275737 cites W1983710378 @default.
- W4302275737 cites W2009050803 @default.
- W4302275737 cites W2010741463 @default.
- W4302275737 cites W2011087509 @default.
- W4302275737 cites W2017338009 @default.
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- W4302275737 cites W2035707307 @default.
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- W4302275737 cites W2100826628 @default.
- W4302275737 cites W2102278945 @default.
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- W4302275737 cites W2234553117 @default.
- W4302275737 cites W2463195069 @default.
- W4302275737 cites W2509948508 @default.
- W4302275737 cites W2512439797 @default.
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- W4302275737 cites W2605356232 @default.
- W4302275737 cites W2736519919 @default.
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- W4302275737 cites W2968426008 @default.
- W4302275737 cites W2977721529 @default.
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- W4302275737 cites W3035672886 @default.
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- W4302275737 cites W3198782993 @default.
- W4302275737 cites W3216866658 @default.
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- W4302275737 cites W4214832799 @default.
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- W4302275737 doi "https://doi.org/10.1242/dev.200920" @default.
- W4302275737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36196602" @default.
- W4302275737 hasPublicationYear "2022" @default.
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