Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302283313> ?p ?o ?g. }
- W4302283313 abstract "The tumor microenvironment (TME) is characterized by discrete changes in metabolic features of cancer and immune cells, with various implications. Cancer cells take up most of the available glucose to support their growth, thereby leaving immune cells with insufficient nutrients to expand. In the relative absence of glucose, T cells switch the metabolic program to lipid-based sources, which is pivotal to T-cell differentiation and activation in nutrient-stressed TME. Although consumption of lipids should provide an alternative energy source to starving T cells, a literature survey has revealed that it may not necessarily lead to antitumor responses. Different subtypes of T cells behave differently in various lipid overload states, which widely depends upon the kind of free fatty acids (FFA) engulfed. Key lipid metabolic genes provide cytotoxic T cells with necessary nutrients for proliferation in the absence of glucose, thereby favoring antitumor immunity, but the same genes cause immune evasion in Tmem and Treg. This review aims to detail the complexity of differential lipid metabolism in distinct subtypes of T cells that drive the antitumor or pro-tumor immunity in specific TME states. We have identified key drug targets related to lipid metabolic rewiring in TME." @default.
- W4302283313 created "2022-10-06" @default.
- W4302283313 creator A5024199652 @default.
- W4302283313 creator A5027417078 @default.
- W4302283313 creator A5036073738 @default.
- W4302283313 creator A5039219524 @default.
- W4302283313 creator A5052077641 @default.
- W4302283313 creator A5068616681 @default.
- W4302283313 creator A5079822453 @default.
- W4302283313 date "2022-10-06" @default.
- W4302283313 modified "2023-10-17" @default.
- W4302283313 title "Lipid metabolic features of T cells in the Tumor Microenvironment" @default.
- W4302283313 cites W11547850 @default.
- W4302283313 cites W1535243328 @default.
- W4302283313 cites W1538172952 @default.
- W4302283313 cites W1561349380 @default.
- W4302283313 cites W1749037810 @default.
- W4302283313 cites W1821802349 @default.
- W4302283313 cites W1840003339 @default.
- W4302283313 cites W1905915630 @default.
- W4302283313 cites W1964010646 @default.
- W4302283313 cites W1965671023 @default.
- W4302283313 cites W1972120590 @default.
- W4302283313 cites W1976714959 @default.
- W4302283313 cites W1982219839 @default.
- W4302283313 cites W1986369171 @default.
- W4302283313 cites W1992511428 @default.
- W4302283313 cites W1992581811 @default.
- W4302283313 cites W1993686673 @default.
- W4302283313 cites W1996363503 @default.
- W4302283313 cites W2008091140 @default.
- W4302283313 cites W2016943504 @default.
- W4302283313 cites W2016983859 @default.
- W4302283313 cites W2025714915 @default.
- W4302283313 cites W2025859745 @default.
- W4302283313 cites W2038904723 @default.
- W4302283313 cites W2041237929 @default.
- W4302283313 cites W2042340425 @default.
- W4302283313 cites W2051218702 @default.
- W4302283313 cites W2054669885 @default.
- W4302283313 cites W2063264144 @default.
- W4302283313 cites W2071523891 @default.
- W4302283313 cites W2075901463 @default.
- W4302283313 cites W2090846942 @default.
- W4302283313 cites W2092893236 @default.
- W4302283313 cites W2097637096 @default.
- W4302283313 cites W2097855813 @default.
- W4302283313 cites W2100039832 @default.
- W4302283313 cites W2101653483 @default.
- W4302283313 cites W2111161262 @default.
- W4302283313 cites W2118107482 @default.
- W4302283313 cites W2118471749 @default.
- W4302283313 cites W2127282925 @default.
- W4302283313 cites W2135272175 @default.
- W4302283313 cites W2141363604 @default.
- W4302283313 cites W2144247138 @default.
- W4302283313 cites W2146791037 @default.
- W4302283313 cites W2152514732 @default.
- W4302283313 cites W2157669002 @default.
- W4302283313 cites W2160551785 @default.
- W4302283313 cites W2160834915 @default.
- W4302283313 cites W2166545988 @default.
- W4302283313 cites W2167432954 @default.
- W4302283313 cites W2170190208 @default.
- W4302283313 cites W2191096966 @default.
- W4302283313 cites W2206617731 @default.
- W4302283313 cites W2289068089 @default.
- W4302283313 cites W2336509969 @default.
- W4302283313 cites W2403002701 @default.
- W4302283313 cites W2404485673 @default.
- W4302283313 cites W2467799705 @default.
- W4302283313 cites W2468497133 @default.
- W4302283313 cites W2488076079 @default.
- W4302283313 cites W2513437047 @default.
- W4302283313 cites W2559152251 @default.
- W4302283313 cites W2560367415 @default.
- W4302283313 cites W2573612572 @default.
- W4302283313 cites W2580719913 @default.
- W4302283313 cites W2597510015 @default.
- W4302283313 cites W2618943818 @default.
- W4302283313 cites W2655262992 @default.
- W4302283313 cites W2734141593 @default.
- W4302283313 cites W2734735597 @default.
- W4302283313 cites W2735809102 @default.
- W4302283313 cites W2736197951 @default.
- W4302283313 cites W2776512049 @default.
- W4302283313 cites W2782676239 @default.
- W4302283313 cites W2783439615 @default.
- W4302283313 cites W2783471328 @default.
- W4302283313 cites W2784164696 @default.
- W4302283313 cites W2784479244 @default.
- W4302283313 cites W2792593720 @default.
- W4302283313 cites W2792873661 @default.
- W4302283313 cites W2797410539 @default.
- W4302283313 cites W2799743239 @default.
- W4302283313 cites W2801330967 @default.
- W4302283313 cites W2885086490 @default.
- W4302283313 cites W2885934772 @default.
- W4302283313 cites W2889218664 @default.
- W4302283313 cites W2899047482 @default.