FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302286465> ?p ?o ?g. }

• W4302286465 abstract "Background COVID-19 associated coagulopathy (CAC) is associated with an increase in thromboembolic events. Current guidelines recommend prophylactic heparins in the management of CAC. However, the efficacy of this strategy in the intensive care population remains uncertain. Objective We aimed to measure thrombin generation (TG) to assess CAC in intensive care unit (ICU) patients receiving thromboprophylaxis with low molecular weight heparin (LMWH) or unfractionated heparin (UFH). In addition, we performed statistical modeling to link TG parameters to patient characteristics and clinical parameters. Lastly, we studied the potency of different anticoagulants as an alternative to LMWH treatment in ex vivo COVID-19 plasma. Patients/Methods We included 33 patients with confirmed COVID-19 admitted at the ICU. TG was measured at least twice over the course of 6 weeks after admission. Thrombin generation parameters peak height and endogenous thrombin potential (ETP) were compared to healthy controls. Results were subsequently correlated with a patient characteristics and laboratory measurements. In vitro spiking in TG with rivaroxaban, dabigatran, argatroban and orgaran was performed and compared to LMWH. Results Anti-Xa levels of all patients remained within the therapeutic range throughout follow-up. At baseline, the mean (SE) endogenous thrombin potential (ETP) was 1,727 (170) nM min and 1,620 (460) nM min for ellagic acid (EA) and tissue factor (TF), respectively. In line with this we found a mean (SE) peak height of 353 (45) nM and 264 (96) nM for EA and TF. Although fluctuating across the weeks of follow-up, TG parameters remained elevated despite thromboprophylaxis. In vitro comparison of LMWHs and direct thrombin inhibitors (e.g., agratroban, dabigatran) revealed a higher efficacy in reducing coagulation potential for direct thrombin inhibition in both ellagic acid (EA) and tissue factor (TF) triggered TG. Conclusion In a sub-group of mechanically ventilated, critically ill COVID-19 patients, despite apparent adequate anti-coagulation doses evaluated by anti-Xa levels, thrombin generation potential remained high during ICU admission independent of age, sex, body mass index, APACHE II score, cardiovascular disease, and smoking status. These observations could, only partially, be explained by (anti)coagulation and thrombosis, inflammation, and multi-organ failure. Our in vitro data suggested that direct thrombin inhibition compared with LMWH might offer an alternate, more effective anticoagulant strategy in COVID-19." @default.
• W4302286465 created "2022-10-06" @default.
• W4302286465 creator A5015341857 @default.
• W4302286465 creator A5022527883 @default.
• W4302286465 creator A5024802434 @default.
• W4302286465 creator A5029495450 @default.
• W4302286465 creator A5034309539 @default.
• W4302286465 creator A5039403992 @default.
• W4302286465 creator A5048053783 @default.
• W4302286465 creator A5055869061 @default.
• W4302286465 creator A5056785549 @default.
• W4302286465 creator A5061124537 @default.
• W4302286465 creator A5068782139 @default.
• W4302286465 creator A5070413635 @default.
• W4302286465 creator A5074000342 @default.
• W4302286465 creator A5076076501 @default.
• W4302286465 date "2022-10-06" @default.
• W4302286465 modified "2023-10-09" @default.
• W4302286465 title "Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort" @default.
• W4302286465 cites W2119768870 @default.
• W4302286465 cites W2599076725 @default.
• W4302286465 cites W3012232836 @default.
• W4302286465 cites W3017485928 @default.
• W4302286465 cites W3019336217 @default.
• W4302286465 cites W3024613607 @default.
• W4302286465 cites W3025747716 @default.
• W4302286465 cites W3025778805 @default.
• W4302286465 cites W3026400664 @default.
• W4302286465 cites W3029923949 @default.
• W4302286465 cites W3036839486 @default.
• W4302286465 cites W3041343166 @default.
• W4302286465 cites W3043483784 @default.
• W4302286465 cites W3048227011 @default.
• W4302286465 cites W3080993830 @default.
• W4302286465 cites W3081892816 @default.
• W4302286465 cites W3082833284 @default.
• W4302286465 cites W3087407141 @default.
• W4302286465 cites W3091459927 @default.
• W4302286465 cites W3094443908 @default.
• W4302286465 cites W3102371316 @default.
• W4302286465 cites W3105653935 @default.
• W4302286465 cites W3109802681 @default.
• W4302286465 cites W3110959641 @default.
• W4302286465 cites W3111980186 @default.
• W4302286465 cites W3112434126 @default.
• W4302286465 cites W3114417951 @default.
• W4302286465 cites W3119796334 @default.
• W4302286465 cites W3122607033 @default.
• W4302286465 cites W3128164510 @default.
• W4302286465 cites W3129075519 @default.
• W4302286465 cites W3129824170 @default.
• W4302286465 cites W3132341048 @default.
• W4302286465 cites W3133754110 @default.
• W4302286465 cites W3154923914 @default.
• W4302286465 cites W3161705187 @default.
• W4302286465 cites W3162739727 @default.
• W4302286465 cites W3164903258 @default.
• W4302286465 cites W3168693390 @default.
• W4302286465 cites W3173699672 @default.
• W4302286465 cites W3187717678 @default.
• W4302286465 cites W3188406547 @default.
• W4302286465 cites W3189488004 @default.
• W4302286465 cites W3189644276 @default.
• W4302286465 cites W3194189472 @default.
• W4302286465 cites W3205277166 @default.
• W4302286465 cites W3214284312 @default.
• W4302286465 cites W4210499980 @default.
• W4302286465 cites W4214851612 @default.
• W4302286465 cites W4225094341 @default.
• W4302286465 cites W4226050201 @default.
• W4302286465 cites W4248429808 @default.
• W4302286465 doi "https://doi.org/10.3389/fcvm.2022.929284" @default.
• W4302286465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36277784" @default.
• W4302286465 hasPublicationYear "2022" @default.
• W4302286465 type Work @default.
• W4302286465 citedByCount "0" @default.
• W4302286465 crossrefType "journal-article" @default.
• W4302286465 hasAuthorship W4302286465A5015341857 @default.
• W4302286465 hasAuthorship W4302286465A5022527883 @default.
• W4302286465 hasAuthorship W4302286465A5024802434 @default.
• W4302286465 hasAuthorship W4302286465A5029495450 @default.
• W4302286465 hasAuthorship W4302286465A5034309539 @default.
• W4302286465 hasAuthorship W4302286465A5039403992 @default.
• W4302286465 hasAuthorship W4302286465A5048053783 @default.
• W4302286465 hasAuthorship W4302286465A5055869061 @default.
• W4302286465 hasAuthorship W4302286465A5056785549 @default.
• W4302286465 hasAuthorship W4302286465A5061124537 @default.
• W4302286465 hasAuthorship W4302286465A5068782139 @default.
• W4302286465 hasAuthorship W4302286465A5070413635 @default.
• W4302286465 hasAuthorship W4302286465A5074000342 @default.
• W4302286465 hasAuthorship W4302286465A5076076501 @default.
• W4302286465 hasBestOaLocation W43022864651 @default.
• W4302286465 hasConcept C126322002 @default.
• W4302286465 hasConcept C177713679 @default.
• W4302286465 hasConcept C2776301958 @default.
• W4302286465 hasConcept C2776376669 @default.
• W4302286465 hasConcept C2776884760 @default.
• W4302286465 hasConcept C2777557582 @default.
• W4302286465 hasConcept C2778205648 @default.
• W4302286465 hasConcept C2778661090 @default.

• next