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• W4302287273 abstract "Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a poor prognosis due to its universal recurrence rate. GBM cells interact with the non-cellular components in the tumor microenvironment (TME), facilitating their rapid growth, evolution, and invasion into the normal brain. Herein we discuss the complexity of the interactions between the cellular and non-cellular components of the TME and advances in the field as a whole. While the stroma of non-central nervous system (CNS) tissues is abundant in fibrillary collagens, laminins, and fibronectin, the normal brain extracellular matrix (ECM) predominantly includes proteoglycans, glycoproteins, and glycosaminoglycans, with fibrillary components typically found only in association with the vasculature. However, recent studies have found that in GBMs, the microenvironment evolves into a more complex array of components, with upregulated collagen gene expression and aligned fibrillary ECM networks. The interactions of glioma cells with the ECM and the degradation of matrix barriers are crucial for both single-cell and collective invasion into neighboring brain tissue. ECM-regulated mechanisms also contribute to immune exclusion, resulting in a major challenge to immunotherapy delivery and efficacy. Glioma cells chemically and physically control the function of their environment, co-opting complex signaling networks for their own benefit, resulting in radio- and chemo-resistance, tumor recurrence, and cancer progression. Targeting these interactions is an attractive strategy for overcoming therapy resistance, and we will discuss recent advances in preclinical studies, current clinical trials, and potential future clinical applications. In this review, we also provide a comprehensive discussion of the complexities of the interconnected cellular and non-cellular components of the microenvironmental landscape of brain tumors to guide the development of safe and effective therapeutic strategies against brain cancer." @default.
• W4302287273 created "2022-10-06" @default.
• W4302287273 creator A5010344742 @default.
• W4302287273 creator A5012916366 @default.
• W4302287273 creator A5036156469 @default.
• W4302287273 creator A5049944456 @default.
• W4302287273 creator A5057475012 @default.
• W4302287273 creator A5065769458 @default.
• W4302287273 creator A5080277287 @default.
• W4302287273 creator A5089609399 @default.
• W4302287273 date "2022-10-06" @default.
• W4302287273 modified "2023-10-10" @default.
• W4302287273 title "The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications" @default.
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