Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302293789> ?p ?o ?g. }
- W4302293789 abstract "Abstract Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a cofactor for collagen maturation. Here, we demonstrate that Vitamin C epigenetically orchestrates osteogenic differentiation and function by modulating chromatin accessibility and priming transcriptional activity. Vitamin C regulates histone demethylation (H3K9me3 and H3K27me3) and promotes TET-mediated 5hmC DNA hydroxymethylation at promoters, enhancers and super-enhancers near bone-specific genes. This epigenetic circuit licenses osteoblastogenesis by permitting the expression of all major pro-osteogenic genes. Osteogenic cell differentiation is strictly and continuously dependent on Vitamin C, whereas Vitamin C is dispensable for adipogenesis. Importantly, deletion of 5hmC-writers, Tet1 and Tet2 , in Vitamin C-sufficient murine bone causes severe skeletal defects which mimic bone phenotypes of Vitamin C-insufficient Gulo knockout mice, a model of Vitamin C deficiency and scurvy. Thus, Vitamin C’s epigenetic functions are central to osteoblastogenesis and bone formation and may be leveraged to prevent common bone-degenerating conditions." @default.
- W4302293789 created "2022-10-06" @default.
- W4302293789 creator A5002355766 @default.
- W4302293789 creator A5003332444 @default.
- W4302293789 creator A5008755139 @default.
- W4302293789 creator A5030845175 @default.
- W4302293789 creator A5031123252 @default.
- W4302293789 creator A5033071737 @default.
- W4302293789 creator A5033664003 @default.
- W4302293789 creator A5035358569 @default.
- W4302293789 creator A5038742778 @default.
- W4302293789 creator A5039689056 @default.
- W4302293789 creator A5043303982 @default.
- W4302293789 creator A5047640338 @default.
- W4302293789 creator A5052731075 @default.
- W4302293789 creator A5054657847 @default.
- W4302293789 creator A5056945892 @default.
- W4302293789 creator A5059947778 @default.
- W4302293789 creator A5070747304 @default.
- W4302293789 creator A5079207425 @default.
- W4302293789 creator A5091408991 @default.
- W4302293789 date "2022-10-06" @default.
- W4302293789 modified "2023-10-17" @default.
- W4302293789 title "Vitamin C epigenetically controls osteogenesis and bone mineralization" @default.
- W4302293789 cites W1558548036 @default.
- W4302293789 cites W1606867770 @default.
- W4302293789 cites W1644877496 @default.
- W4302293789 cites W1816879501 @default.
- W4302293789 cites W1945798309 @default.
- W4302293789 cites W1965956854 @default.
- W4302293789 cites W1971578941 @default.
- W4302293789 cites W1979255076 @default.
- W4302293789 cites W1979594866 @default.
- W4302293789 cites W1985605815 @default.
- W4302293789 cites W1997409763 @default.
- W4302293789 cites W1997453048 @default.
- W4302293789 cites W2003622980 @default.
- W4302293789 cites W2015536893 @default.
- W4302293789 cites W2016923091 @default.
- W4302293789 cites W2022481684 @default.
- W4302293789 cites W2022826738 @default.
- W4302293789 cites W2023765801 @default.
- W4302293789 cites W2024929839 @default.
- W4302293789 cites W2025099538 @default.
- W4302293789 cites W2026159178 @default.
- W4302293789 cites W2038449573 @default.
- W4302293789 cites W2054281547 @default.
- W4302293789 cites W2055171457 @default.
- W4302293789 cites W2060736241 @default.
- W4302293789 cites W2062277727 @default.
- W4302293789 cites W2063428822 @default.
- W4302293789 cites W2073587729 @default.
- W4302293789 cites W2073979766 @default.
- W4302293789 cites W2077520032 @default.
- W4302293789 cites W2081959933 @default.
- W4302293789 cites W2093191361 @default.
- W4302293789 cites W2097237102 @default.
- W4302293789 cites W2108244474 @default.
- W4302293789 cites W2108998830 @default.
- W4302293789 cites W2109441210 @default.
- W4302293789 cites W2139796090 @default.
- W4302293789 cites W2141763464 @default.
- W4302293789 cites W2141856502 @default.
- W4302293789 cites W2152425341 @default.
- W4302293789 cites W2160295144 @default.
- W4302293789 cites W2165276620 @default.
- W4302293789 cites W2167110353 @default.
- W4302293789 cites W2171750286 @default.
- W4302293789 cites W2186733243 @default.
- W4302293789 cites W2204840988 @default.
- W4302293789 cites W2238643726 @default.
- W4302293789 cites W2483061037 @default.
- W4302293789 cites W2523019565 @default.
- W4302293789 cites W2535659667 @default.
- W4302293789 cites W2623735819 @default.
- W4302293789 cites W2746373891 @default.
- W4302293789 cites W2766548989 @default.
- W4302293789 cites W2776532474 @default.
- W4302293789 cites W2797659137 @default.
- W4302293789 cites W2801924666 @default.
- W4302293789 cites W2806681913 @default.
- W4302293789 cites W2887663418 @default.
- W4302293789 cites W2898312627 @default.
- W4302293789 cites W2908091705 @default.
- W4302293789 cites W2911327473 @default.
- W4302293789 cites W2912582309 @default.
- W4302293789 cites W2914844813 @default.
- W4302293789 cites W2920365598 @default.
- W4302293789 cites W2963301787 @default.
- W4302293789 cites W2966390440 @default.
- W4302293789 cites W2971783845 @default.
- W4302293789 cites W2993062212 @default.
- W4302293789 cites W2999019483 @default.
- W4302293789 cites W3027751413 @default.
- W4302293789 cites W3108971791 @default.
- W4302293789 cites W3115666253 @default.
- W4302293789 cites W3134456529 @default.
- W4302293789 cites W3138770880 @default.
- W4302293789 cites W3208518221 @default.
- W4302293789 cites W4200215171 @default.