FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302303896> ?p ?o ?g. }

• W4302303896 abstract "There's no evidence demonstrating the association between noncoding RNAs levels before IV recombinant tissue plasminogen activator (rtPA) administration and the outcomes of acute ischemic stroke (AIS). 145 AIS patients received rtPA treatment were recruited at the stroke center from 2018 to 2019, and 103 patients were included in this study. A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. Endpoints included excellent outcome (modified Rankin Scale score [mRS] 0-1) or poor outcome (mRS > 1) at 3 months and symptomatic intracerebral hemorrhage (sICH) after rtPA treatment. Among the eight noncoding RNAs detected in circulating neutrophils of the 103 participants, miRNA-23a levels were associated with the stroke severity on admission and symptom progression at 24 h after rtPA treatment. A noncoding RNA score composed of miRNA-23a, miRNA-99a, and lncRNA H19 was screened to predict the functional outcome at 3 months and the incidence of sICH after rtPA treatment. In the logistic regression analysis, the noncoding RNA score ≥ -0.336 (OR = 2.862 [1.029-7.958], p = 0.044) was an independent predictor of the poor outcome at 3 months after adjustment of clinical variables, the addition of the noncoding RNA score to the clinical model improved the discrimination (IDI% = 4.68 [0.65-8.71], p = 0.020), as well as the net reclassification (NRI% = 33.04 [0.54-71.49], p = 0.016). The noncoding RNA score ≥ -0.336 (OR = 5.250 [1.096-25.135], p = 0.038) was also independently predicted the sICH, the addition of the noncoding RNA score to the clinical variables improved discrimination and reclassification as well. The noncoding RNA score was also associated with the infarct volume and symptom improvement at 7 days after rtPA treatment. In conclusion, a higher neutrophilic noncoding RNA score provides predictive value to identify AIS patients with worse outcomes after rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS." @default.
• W4302303896 created "2022-10-06" @default.
• W4302303896 creator A5011765763 @default.
• W4302303896 creator A5015450494 @default.
• W4302303896 creator A5040662666 @default.
• W4302303896 creator A5055336038 @default.
• W4302303896 creator A5058271872 @default.
• W4302303896 creator A5074538925 @default.
• W4302303896 creator A5076100172 @default.
• W4302303896 creator A5078037174 @default.
• W4302303896 creator A5081191891 @default.
• W4302303896 creator A5082664929 @default.
• W4302303896 date "2022-10-06" @default.
• W4302303896 modified "2023-09-30" @default.
• W4302303896 title "Neutrophilic noncoding RNAs predict outcomes of acute ischemic stroke patients treated with recombinant tissue plasminogen activator" @default.
• W4302303896 cites W1480729244 @default.
• W4302303896 cites W1503485798 @default.
• W4302303896 cites W1644190097 @default.
• W4302303896 cites W186716551 @default.
• W4302303896 cites W1969661146 @default.
• W4302303896 cites W1997064745 @default.
• W4302303896 cites W2005130936 @default.
• W4302303896 cites W2024419054 @default.
• W4302303896 cites W2027123157 @default.
• W4302303896 cites W2067395123 @default.
• W4302303896 cites W2079911401 @default.
• W4302303896 cites W2081181376 @default.
• W4302303896 cites W2138595885 @default.
• W4302303896 cites W2152575748 @default.
• W4302303896 cites W2162729327 @default.
• W4302303896 cites W2549104904 @default.
• W4302303896 cites W2608546139 @default.
• W4302303896 cites W2661470941 @default.
• W4302303896 cites W2750205082 @default.
• W4302303896 cites W2757427599 @default.
• W4302303896 cites W2794616387 @default.
• W4302303896 cites W2799655960 @default.
• W4302303896 cites W2894699074 @default.
• W4302303896 cites W2936461784 @default.
• W4302303896 cites W2942648532 @default.
• W4302303896 cites W2967583138 @default.
• W4302303896 cites W2974078113 @default.
• W4302303896 cites W2982303713 @default.
• W4302303896 cites W2997294045 @default.
• W4302303896 cites W3014874854 @default.
• W4302303896 cites W3021053192 @default.
• W4302303896 cites W3022809827 @default.
• W4302303896 cites W3093087790 @default.
• W4302303896 cites W3093119237 @default.
• W4302303896 cites W3096204191 @default.
• W4302303896 cites W3118158112 @default.
• W4302303896 cites W3132340173 @default.
• W4302303896 cites W4221126856 @default.
• W4302303896 cites W4285174564 @default.
• W4302303896 doi "https://doi.org/10.3389/fphar.2022.1003806" @default.
• W4302303896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36278201" @default.
• W4302303896 hasPublicationYear "2022" @default.
• W4302303896 type Work @default.
• W4302303896 citedByCount "2" @default.
• W4302303896 countsByYear W43023038962023 @default.
• W4302303896 crossrefType "journal-article" @default.
• W4302303896 hasAuthorship W4302303896A5011765763 @default.
• W4302303896 hasAuthorship W4302303896A5015450494 @default.
• W4302303896 hasAuthorship W4302303896A5040662666 @default.
• W4302303896 hasAuthorship W4302303896A5055336038 @default.
• W4302303896 hasAuthorship W4302303896A5058271872 @default.
• W4302303896 hasAuthorship W4302303896A5074538925 @default.
• W4302303896 hasAuthorship W4302303896A5076100172 @default.
• W4302303896 hasAuthorship W4302303896A5078037174 @default.
• W4302303896 hasAuthorship W4302303896A5081191891 @default.
• W4302303896 hasAuthorship W4302303896A5082664929 @default.
• W4302303896 hasBestOaLocation W43023038961 @default.
• W4302303896 hasConcept C104317684 @default.
• W4302303896 hasConcept C126322002 @default.
• W4302303896 hasConcept C143998085 @default.
• W4302303896 hasConcept C145059251 @default.
• W4302303896 hasConcept C151956035 @default.
• W4302303896 hasConcept C194993378 @default.
• W4302303896 hasConcept C2776572282 @default.
• W4302303896 hasConcept C2777094939 @default.
• W4302303896 hasConcept C2777736543 @default.
• W4302303896 hasConcept C2778820722 @default.
• W4302303896 hasConcept C2780931571 @default.
• W4302303896 hasConcept C3020199598 @default.
• W4302303896 hasConcept C541997718 @default.
• W4302303896 hasConcept C54355233 @default.
• W4302303896 hasConcept C60644358 @default.
• W4302303896 hasConcept C62203573 @default.
• W4302303896 hasConcept C67705224 @default.
• W4302303896 hasConcept C71924100 @default.
• W4302303896 hasConcept C86803240 @default.
• W4302303896 hasConceptScore W4302303896C104317684 @default.
• W4302303896 hasConceptScore W4302303896C126322002 @default.
• W4302303896 hasConceptScore W4302303896C143998085 @default.
• W4302303896 hasConceptScore W4302303896C145059251 @default.
• W4302303896 hasConceptScore W4302303896C151956035 @default.
• W4302303896 hasConceptScore W4302303896C194993378 @default.
• W4302303896 hasConceptScore W4302303896C2776572282 @default.
• W4302303896 hasConceptScore W4302303896C2777094939 @default.
• W4302303896 hasConceptScore W4302303896C2777736543 @default.

• next