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- W4302373737 abstract "In early 1983, an outbreak of illness caused by raw milk contaminated with multiple-antimicrobial-resistant<i>Salmonella typhimurium</i>occurred in Arizona. One of the cases involved a 72-year-old woman who died with<i>Salmonella</i>enteritis and sepsis that had not responded to treatment with chloramphenicol. The<i>S typhimurium</i>isolates from this patient, from other ill persons, and from raw milk were resistant to ampicillin, chloramphenicol, kanamycin sulfate, streptomycin, sulfonamide, and tetracycline. These resistances were mediated by a 105-megadalton R plasmid. During the epidemic period, 43% of the<i>S typhimurium</i>isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance. Although there was evidence of spread of the<i>S typhimurium</i>in the community, there was no evidence of spread of this<i>Salmonella</i>R plasmid to the normal flora of patients or their family members a median of 14 weeks after the infection. This outbreak demonstrates the ability of drug-resistant<i>Salmonella</i>to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection. (<i>JAMA</i>1985;253:2058-2060)" @default.
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- W4302373737 date "1985-04-12" @default.
- W4302373737 modified "2023-10-14" @default.
- W4302373737 title "An Outbreak of Multiple-Drug-Resistant Salmonella Enteritis From Raw Milk" @default.
- W4302373737 doi "https://doi.org/10.1001/jama.1985.03350380074024" @default.
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