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- W4302424774 abstract "To support life, the osmolality of the cellular fluid is tightly regulated by various means, including osmolyte control. Dicarbonyl/L-xylulose reductase (DCXR) is a highly conserved enzyme reducing L-xylulose to xylitol, which serves as an effective osmolyte in various mammalian and human tissues such as lung epithelium, sperm, and lens. DHS-21 is the only DCXR ortholog in Caenorhabditis elegans, and DCXR null mutant worms accumulate eggs in the uterus. However, it has been unknown how and why the mutant worms impair egg retention. In this study, we tested whether the egg-retention in dhs-21 (jh129), the DCXR null mutant worm, is sensitive to changes in osmolarity. Low osmolality reverted the egg retention phenotype of dhs-21(jh129), while high osmolarity aggravated it. Also, knock-down of either one of osr-1, osm-7, or osm-11, osmoregulatory genes, also rescued egg-retention phenotypes of the null mutants. The study indicates that DCXR functions in fluid homeostasis by regulating cellular osmolality in C. elegans and provides insights into DCXR-involved clinical conditions, such as congenital cataracts and malfunctioning lung and kidney." @default.
- W4302424774 created "2022-10-06" @default.
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- W4302424774 date "2022-09-03" @default.
- W4302424774 modified "2023-09-30" @default.
- W4302424774 title "Dicarbonyl/L-xylulose reductase (DCXR) producing xylitol regulates egg retention through osmolality control in <i>Caenorhabditis elegans</i>" @default.
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- W4302424774 doi "https://doi.org/10.1080/19768354.2022.2126886" @default.
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