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- W4302425325 abstract "The dormant state of bacterial spores is generally thought to be devoid of biological activity. We show that despite continued dormancy, spores can integrate environmental signals over time through a preexisting electrochemical potential. Specifically, we studied thousands of individual Bacillus subtilis spores that remain dormant when exposed to transient nutrient pulses. Guided by a mathematical model of bacterial electrophysiology, we modulated the decision to exit dormancy by genetically and chemically targeting potassium ion flux. We confirmed that short nutrient pulses result in step-like changes in the electrochemical potential of persistent spores. During dormancy, spores thus gradually release their stored electrochemical potential to integrate extracellular information over time. These findings reveal a decision-making mechanism that operates in physiologically inactive cells." @default.
- W4302425325 created "2022-10-06" @default.
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- W4302425325 date "2022-10-07" @default.
- W4302425325 modified "2023-10-17" @default.
- W4302425325 title "Electrochemical potential enables dormant spores to integrate environmental signals" @default.
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- W4302425325 doi "https://doi.org/10.1126/science.abl7484" @default.
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