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- W4302426002 abstract "Abstract “Blindness separates from things; deafness separates from people.” This quote attributed to the deaf-blind author and activist Helen Keller (1880–1968) indicates the importance of proper hearing for social interaction in our society which is largely driven by acoustic communication. A major cause for auditory dysfunction lies in our genome with currently more than 100 genes linked to hearing loss. One example is the microRNA gene Mir-96 of the microRNA-183 family. MicroRNAs are small regulatory RNAs involved in the finetuning of gene expression. Analyses of transgenic mouse models established this microRNA family as a major regulator for the function of the inner ear as well as synaptic transmission in the auditory brainstem. The microRNA-183 family might therefore play an important role in coordinating the development of the peripheral and central auditory system and their specializations." @default.
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- W4302426002 date "2022-10-07" @default.
- W4302426002 modified "2023-09-30" @default.
- W4302426002 title "MicroRNAs in the auditory system: tiny molecules with big impact" @default.
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- W4302426002 doi "https://doi.org/10.1515/nf-2022-0016" @default.
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