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- W4302439400 abstract "The metabolism of the antiviral drug tromantadine (1-adamantyl-2-(2-dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatography/mass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1-aminoadamantane (amantadine) and 1-adamantyl-(2-hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol." @default.
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- W4302439400 date "1985-09-01" @default.
- W4302439400 modified "2023-10-01" @default.
- W4302439400 title "The metabolism of tromantadine" @default.
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- W4302439400 doi "https://doi.org/10.1002/bms.1200120909" @default.
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