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• W4302760925 abstract "Abstract: In coronavirus disease 2019 (COVID-19), thrombus formation is related to the pathogen-esis of acute respiratory distress syndrome (ARDS) and the progression of clinical symptoms. Se-vere damage to vascular endothelial cells and the associated cytokine storm after SARS-CoV-2 in-fection cause thrombogenesis and contribute to the development of more severe and unique throm-boses compared to other infectious diseases. Thromboses occur more often in critically ill patients. In addition to pulmonary thromboembolism (PE) and deep vein thrombosis, acute myocardial in-farction, peripheral arterial thrombosis, and aortic thrombosis have also been reported. In PE, thrombi develop in both pulmonary arteries and alveolar capillaries. These, together with intra-alveolar fibrin deposition, interfere with effective gaseous exchange in the lungs and exacerbate the clinical symptoms of ARDS in patients with COVID-19. Pharmacological thromboprophylaxis is recommended for all hospitalized patients to prevent both thrombosis and aggravation of ARDS, and other organ failures. Although the pediatric population is mostly asymptomatic or develops mild disease after SARS-CoV-2 infection, a new inflammatory disorder affecting the cardiovascular system, multisystem inflammatory syndrome in children (MIS-C), has been reported. Similar to Kawasaki disease, acute myocarditis, coronary vasculitis, and aneurysms are typically seen in MIS-C, although these two are now considered distinct entities. A similar acute myocarditis is also ob-served in young male adults, in which a hyperinflammatory state after SARS-CoV-2 infection seems to be involved. Several side effects following vaccination against COVID-19 have been re-ported, including vaccine-induced immune thrombotic thrombocytopenia and acute myocarditis. Although these could be serious and life-threatening, the cases are very rare, thus, the benefits of immunization still outweigh the risks." @default.
• W4302760925 created "2022-10-07" @default.
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• W4302760925 date "2022-12-01" @default.
• W4302760925 modified "2023-09-23" @default.
• W4302760925 title "COVID-19 and Thrombosis: Clinical Aspects" @default.
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• W4302760925 doi "https://doi.org/10.2174/1389450123666221005092350" @default.
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