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• W4302773290 abstract "An important goal of the Hepatitis E virus (HEV) vaccine is to prevent adverse pregnancy outcomes caused by different HEV genotypes during pregnancy, but studies directly evaluating maternal vaccination for HEV are lacking. Here we report maternal vaccination using HEV 239 vaccine in a pregnant rabbit model. Two dose of accelerated vaccination schedule (0, 7 days) induced high titers of anti-HEV protective antibodies in a short period of time in pregnant rabbits, which could protect the pregnant rabbits from HEV infection and adverse pregnancy outcomes. In addition, the immunized rabbits transfer maternal antibodies to pups through the placenta and breast milk, which protect neonates against HEV infection. Our results suggest that, besides vaccinating nonpregnant individuals, HEV 239 vaccine may also be discreetly considered for maternal vaccination." @default.
• W4302773290 created "2022-10-07" @default.
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• W4302773290 date "2022-10-27" @default.
• W4302773290 modified "2023-09-22" @default.
• W4302773290 title "Efficacy of an accelerated vaccination schedule against hepatitis E virus infection in pregnant rabbits" @default.
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• W4302773290 doi "https://doi.org/10.1002/jmv.28193" @default.
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• W4302773290 hasPublicationYear "2022" @default.
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