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- W4302773390 startingPage "707" @default.
- W4302773390 abstract "Over the past two decades, understanding of hepatic macrophage biology has provided astounding details of their role in the progression and regression of liver diseases. The hepatic macrophages constitute resident macrophages, Kupffer cells, and circulating bone marrow monocyte-derived macrophages, which play a diverse role in liver injury and repair. Imbalance in the macrophage population leads to pathological consequences and is responsible for the initiation and progression of acute and chronic liver injuries. Further, distinct populations of hepatic macrophages and their high heterogeneity make their complex role enigmatic. The unique features of distinct phenotypes of macrophages have provided novel biomarkers for defining the stages of liver diseases. The distinct mechanisms of hepatic macrophages polarization and recruitment have been at the fore front of research. In addition, the secretome of hepatic macrophages and their immune regulation has provided clinically relevant therapeutic targets.Herein, we have highlighted the current understanding in the area of hepatic macrophages, and their role in the progression of liver injury.It is essential to ascertain the physiological and pathological role of evolutionarily conserved distinct macrophage phenotypes in different liver diseases before viable approaches may see a clinical translation." @default.
- W4302773390 created "2022-10-07" @default.
- W4302773390 creator A5042737050 @default.
- W4302773390 creator A5055719124 @default.
- W4302773390 creator A5057742598 @default.
- W4302773390 creator A5083718300 @default.
- W4302773390 creator A5088098310 @default.
- W4302773390 date "2022-08-03" @default.
- W4302773390 modified "2023-10-17" @default.
- W4302773390 title "Spotlight on liver macrophages for halting liver disease progression and injury" @default.
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