FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4302774310> ?p ?o ?g. }

• W4302774310 abstract "Summary The ATP-sensitive K + channel (K ATP ) is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice, we demonstrate that a glycolytic metabolon locally controls K ATP channels on the plasma membrane. The two ATP-consuming enzymes of upper glycolysis, glucokinase and phosphofructokinase, generate ADP that activates K ATP . Substrate channeling of fructose 1,6-bisphosphate through the enzymes of lower glycolysis fuels pyruvate kinase, which directly consumes the ADP made by phosphofructokinase to raise ATP/ADP and close the channel. We further demonstrate the presence of a plasma membrane NAD + /NADH cycle, whereby lactate dehydrogenase is functionally coupled to glyceraldehyde-3-phosphate dehydrogenase. These studies provide direct electrophysiological evidence of a K ATP -controlling glycolytic signaling complex and demonstrate its relevance to islet glucose sensing and excitability. Graphical abstract Ho et al . demonstrate that the enzymes of glycolysis, as well as lactate dehydrogenase, form a plasma membrane-associated metabolon with intrinsic ATP/ADP and NAD + /NADH cycles. The subcellular location of this signaling complex allows both ATP-consuming and ATP-producing enzymes to locally control the activity of ATP-sensitive K + channels in pancreatic α and β cells from humans and mice. Highlights K ATP channels are regulated by a glycolytic metabolon on the plasma membrane. Substrate channeling occurs between the consecutive enzymes of glycolysis. Upper glycolysis produces ADP that is used directly by lower glycolysis to make ATP. LDH and GADPH facilitate a plasma membrane-associated NAD + /NADH redox cycle." @default.
• W4302774310 created "2022-10-07" @default.
• W4302774310 creator A5026242337 @default.
• W4302774310 creator A5036050814 @default.
• W4302774310 creator A5044916299 @default.
• W4302774310 creator A5048024323 @default.
• W4302774310 date "2022-10-06" @default.
• W4302774310 modified "2023-09-29" @default.
• W4302774310 title "A plasma membrane-associated glycolytic metabolon is functionally coupled to K_ATPchannels in pancreatic α and β cells from humans and mice" @default.
• W4302774310 cites W1491974553 @default.
• W4302774310 cites W1749560786 @default.
• W4302774310 cites W1965117098 @default.
• W4302774310 cites W1972238666 @default.
• W4302774310 cites W1975347125 @default.
• W4302774310 cites W1977578342 @default.
• W4302774310 cites W1980184724 @default.
• W4302774310 cites W1985770721 @default.
• W4302774310 cites W1994924615 @default.
• W4302774310 cites W1997849672 @default.
• W4302774310 cites W2005150634 @default.
• W4302774310 cites W2007360886 @default.
• W4302774310 cites W2017518453 @default.
• W4302774310 cites W2020024927 @default.
• W4302774310 cites W2022092956 @default.
• W4302774310 cites W2033143899 @default.
• W4302774310 cites W2043566189 @default.
• W4302774310 cites W2047491209 @default.
• W4302774310 cites W2051514397 @default.
• W4302774310 cites W2054123807 @default.
• W4302774310 cites W2070184989 @default.
• W4302774310 cites W2071824475 @default.
• W4302774310 cites W2080277761 @default.
• W4302774310 cites W2089015042 @default.
• W4302774310 cites W2101627628 @default.
• W4302774310 cites W2104482284 @default.
• W4302774310 cites W2119977310 @default.
• W4302774310 cites W2127375515 @default.
• W4302774310 cites W2127761531 @default.
• W4302774310 cites W2140653555 @default.
• W4302774310 cites W2153022805 @default.
• W4302774310 cites W2153863351 @default.
• W4302774310 cites W2160551785 @default.
• W4302774310 cites W2161062891 @default.
• W4302774310 cites W2163595098 @default.
• W4302774310 cites W2168519910 @default.
• W4302774310 cites W2305919687 @default.
• W4302774310 cites W2516174717 @default.
• W4302774310 cites W2551194178 @default.
• W4302774310 cites W2585333920 @default.
• W4302774310 cites W2622190181 @default.
• W4302774310 cites W2738634672 @default.
• W4302774310 cites W2744290711 @default.
• W4302774310 cites W2901208726 @default.
• W4302774310 cites W3043439586 @default.
• W4302774310 cites W3045799079 @default.
• W4302774310 cites W3083922191 @default.
• W4302774310 cites W3095557901 @default.
• W4302774310 cites W3096903800 @default.
• W4302774310 cites W3125755970 @default.
• W4302774310 cites W312902049 @default.
• W4302774310 cites W3135663312 @default.
• W4302774310 cites W3161199858 @default.
• W4302774310 cites W3207492948 @default.
• W4302774310 cites W4220939188 @default.
• W4302774310 cites W4283155695 @default.
• W4302774310 cites W4292731226 @default.
• W4302774310 doi "https://doi.org/10.1101/2022.10.06.511200" @default.
• W4302774310 hasPublicationYear "2022" @default.
• W4302774310 type Work @default.
• W4302774310 citedByCount "1" @default.
• W4302774310 countsByYear W43027743102022 @default.
• W4302774310 crossrefType "posted-content" @default.
• W4302774310 hasAuthorship W4302774310A5026242337 @default.
• W4302774310 hasAuthorship W4302774310A5036050814 @default.
• W4302774310 hasAuthorship W4302774310A5044916299 @default.
• W4302774310 hasAuthorship W4302774310A5048024323 @default.
• W4302774310 hasBestOaLocation W43027743101 @default.
• W4302774310 hasConcept C122245378 @default.
• W4302774310 hasConcept C181199279 @default.
• W4302774310 hasConcept C185592680 @default.
• W4302774310 hasConcept C20251656 @default.
• W4302774310 hasConcept C55493867 @default.
• W4302774310 hasConcept C75520062 @default.
• W4302774310 hasConcept C86803240 @default.
• W4302774310 hasConcept C95444343 @default.
• W4302774310 hasConcept C98335778 @default.
• W4302774310 hasConceptScore W4302774310C122245378 @default.
• W4302774310 hasConceptScore W4302774310C181199279 @default.
• W4302774310 hasConceptScore W4302774310C185592680 @default.
• W4302774310 hasConceptScore W4302774310C20251656 @default.
• W4302774310 hasConceptScore W4302774310C55493867 @default.
• W4302774310 hasConceptScore W4302774310C75520062 @default.
• W4302774310 hasConceptScore W4302774310C86803240 @default.
• W4302774310 hasConceptScore W4302774310C95444343 @default.
• W4302774310 hasConceptScore W4302774310C98335778 @default.
• W4302774310 hasLocation W43027743101 @default.
• W4302774310 hasOpenAccess W4302774310 @default.
• W4302774310 hasPrimaryLocation W43027743101 @default.
• W4302774310 hasRelatedWork W1931404067 @default.
• W4302774310 hasRelatedWork W1967502944 @default.

• next