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- W4302991566 abstract "Malignant hyperpyrexia with muscular rigidity occurred in five patients during general anaesthesia, suxamethonium and halothane being used. In three patients the condition was fatal, and members of their families were investigated by motorpoint muscle biopsy. Two further patients recovered and were examined in the same way at a later date along with relatives. The excised muscle of some members of each family and of the two surviving index patients was shown to react in vitro to halothane by contracture. These reactors were considered liable to develop malignant hyperpyrexia. All reactors had structurally abnormal muscle, but the myopathy was variably expressed. Its histopathological and histochemical characteristics are described, and are held to be significant in three families, possibly coincidental in the fourth owing to coexistent systemic disease, and slight and of uncertain significance in the fifth. Clinical signs of muscular hypertrophy, atrophy, or diminished or absent deep reflexes were found in two patients; in all reactors the myopathy was asymptomatic. Serum creatine phosphokinase estimation was not reliable in the detection of malignant hyperpyrexia myopathy, which requires motor-point muscle biopsy with structural and neuropharmacological investigation for its accurate delineation." @default.
- W4302991566 created "2022-10-07" @default.
- W4302991566 date "1973-10-01" @default.
- W4302991566 modified "2023-09-30" @default.
- W4302991566 title "Malignant Hyperpyrexia Myopathy" @default.
- W4302991566 doi "https://doi.org/10.1093/oxfordjournals.qjmed.a067358" @default.
- W4302991566 hasPublicationYear "1973" @default.
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