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- W4303045401 abstract "N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on the epigenetic regulation of mRNAs that is ubiquitously present in eukaryotes. Abnormal changes in m6A levels are closely related to the regulation of RNA metabolism, heat shock stress, tumor occurrence, and development. m6A modifications are catalyzed by the m6A writer complex, which contains RNA methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP), and other proteins with methyltransferase (MTase) capability, such as RNA-binding motif protein 15 (RBM15), KIAA1429 and zinc finger CCCH-type containing 13 (ZC3H13). Although METTL3 is the main catalytic subunit, WTAP is a regulatory subunit whose function is to recruit the m6A methyltransferase complex to the target mRNA. Specifically, WTAP is required for the accumulation of METTL3 and METTL14 in nuclear speckles. In this paper, we briefly introduce the molecular mechanism of m6A modification. Then, we focus on WTAP, a component of the m6A methyltransferase complex, and introduce its structure, localization, and physiological functions. Finally, we describe its roles and mechanisms in cancer." @default.
- W4303045401 created "2022-10-07" @default.
- W4303045401 creator A5002383765 @default.
- W4303045401 creator A5009404752 @default.
- W4303045401 creator A5042059280 @default.
- W4303045401 creator A5049965997 @default.
- W4303045401 creator A5083271100 @default.
- W4303045401 date "2022-10-07" @default.
- W4303045401 modified "2023-10-16" @default.
- W4303045401 title "The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms" @default.
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