Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303194611> ?p ?o ?g. }
- W4303194611 endingPage "186" @default.
- W4303194611 startingPage "173" @default.
- W4303194611 abstract "Phage therapy is one of the alternatives to treat infections caused by both antibiotic-sensitive and antibiotic-resistant bacteria, with no or low toxicity to patients. It was started a century ago, although rapidly growing bacterial antimicrobial resistance, resulting in high levels of morbidity, mortality, and financial cost, has initiated the revival of phage therapy. It involves the use of live lytic, bioengineered, phage-encoded biological products, in combination with chemical antibiotics to treat bacterial infections. Importantly, phages will be removed from the body within seven days of clearing an infection. They target specific bacterial strains and cause minimal disruption to the microbial balance in humans. Phages for medication must be screened for the absence of resistant genes, virulent genes, cytotoxicity, and their interaction with the host tissue and organs. Since they are immunogenic, applying a high phage titer for therapy exposes them and activates the host immune system. To date, no serious side effects have been reported with human phage therapy. In this review, we describe phage-phagocyte interaction, bacterial resistance to phages, how phages conquer bacterial resistance, the role of genetic engineering and other technologies in phage therapy, and the therapeutic application of modified phages and phage-encoded products. We also highlight the comparison of antibiotics and lytic phage therapy, the pros and cons of phage therapy, determinants of human phage therapy trials, phage quality and safety requirements, phage storage and handling, and current challenges in phage therapy." @default.
- W4303194611 created "2022-10-07" @default.
- W4303194611 creator A5018765887 @default.
- W4303194611 creator A5022694107 @default.
- W4303194611 creator A5036881583 @default.
- W4303194611 creator A5053223236 @default.
- W4303194611 date "2022-10-01" @default.
- W4303194611 modified "2023-09-25" @default.
- W4303194611 title "Phage Therapy: A Different Approach to Fight Bacterial Infections" @default.
- W4303194611 cites W1534386309 @default.
- W4303194611 cites W1565304611 @default.
- W4303194611 cites W1691012859 @default.
- W4303194611 cites W1700071556 @default.
- W4303194611 cites W1770004780 @default.
- W4303194611 cites W1902380478 @default.
- W4303194611 cites W1972165442 @default.
- W4303194611 cites W1972969288 @default.
- W4303194611 cites W1974881706 @default.
- W4303194611 cites W1978116622 @default.
- W4303194611 cites W1992196067 @default.
- W4303194611 cites W2006494972 @default.
- W4303194611 cites W2011957174 @default.
- W4303194611 cites W2013330518 @default.
- W4303194611 cites W2013956986 @default.
- W4303194611 cites W2019197162 @default.
- W4303194611 cites W2024931582 @default.
- W4303194611 cites W2040274090 @default.
- W4303194611 cites W2041988218 @default.
- W4303194611 cites W2043070150 @default.
- W4303194611 cites W2043083543 @default.
- W4303194611 cites W2052192736 @default.
- W4303194611 cites W2056959577 @default.
- W4303194611 cites W2057757399 @default.
- W4303194611 cites W2070190014 @default.
- W4303194611 cites W2070284460 @default.
- W4303194611 cites W2072260227 @default.
- W4303194611 cites W2075575047 @default.
- W4303194611 cites W2077157239 @default.
- W4303194611 cites W2097379120 @default.
- W4303194611 cites W2097999790 @default.
- W4303194611 cites W2098621809 @default.
- W4303194611 cites W2099539515 @default.
- W4303194611 cites W2106543475 @default.
- W4303194611 cites W2108312133 @default.
- W4303194611 cites W2108585371 @default.
- W4303194611 cites W2108666079 @default.
- W4303194611 cites W2115980188 @default.
- W4303194611 cites W2117085296 @default.
- W4303194611 cites W2117604880 @default.
- W4303194611 cites W2117840807 @default.
- W4303194611 cites W2120327993 @default.
- W4303194611 cites W2123978130 @default.
- W4303194611 cites W2126115772 @default.
- W4303194611 cites W2135598273 @default.
- W4303194611 cites W2139150373 @default.
- W4303194611 cites W2151516032 @default.
- W4303194611 cites W2154984047 @default.
- W4303194611 cites W2155560009 @default.
- W4303194611 cites W2156738105 @default.
- W4303194611 cites W2160719299 @default.
- W4303194611 cites W2169244146 @default.
- W4303194611 cites W2171338508 @default.
- W4303194611 cites W2259283542 @default.
- W4303194611 cites W2311297659 @default.
- W4303194611 cites W2395104290 @default.
- W4303194611 cites W2404250771 @default.
- W4303194611 cites W2416820840 @default.
- W4303194611 cites W2462068747 @default.
- W4303194611 cites W2470353668 @default.
- W4303194611 cites W2515445040 @default.
- W4303194611 cites W2521222124 @default.
- W4303194611 cites W2552957870 @default.
- W4303194611 cites W2598483877 @default.
- W4303194611 cites W2609657861 @default.
- W4303194611 cites W2626400269 @default.
- W4303194611 cites W2731699938 @default.
- W4303194611 cites W2741628575 @default.
- W4303194611 cites W2746479077 @default.
- W4303194611 cites W2786093221 @default.
- W4303194611 cites W2796042626 @default.
- W4303194611 cites W2802084040 @default.
- W4303194611 cites W2811180668 @default.
- W4303194611 cites W2889407639 @default.
- W4303194611 cites W2897254003 @default.
- W4303194611 cites W2901652748 @default.
- W4303194611 cites W2905810822 @default.
- W4303194611 cites W2906837763 @default.
- W4303194611 cites W2911362701 @default.
- W4303194611 cites W2913871048 @default.
- W4303194611 cites W2952486212 @default.
- W4303194611 cites W2952919847 @default.
- W4303194611 cites W29620779 @default.
- W4303194611 cites W2971331926 @default.
- W4303194611 cites W2972127693 @default.
- W4303194611 cites W2980313137 @default.
- W4303194611 cites W3004537458 @default.
- W4303194611 cites W3004847400 @default.
- W4303194611 cites W3011910186 @default.