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• W4303423812 abstract "Gammaherpesviruses establish life-long infection in over 95% of adults and are associated with several cancers, including B cell lymphomas. Using the murine gammaherpesvirus 68 (MHV68) animal model, we previously showed a pro-viral role of Interleukin-1 (IL-1) signaling that supported viral reactivation during the establishment of chronic infection. Unexpectedly, in this study we found that the proviral effects of IL-1 signaling originally observed during the establishment of chronic gammaherpesvirus infection convert to antiviral effects during the long-term stage of infection. Specifically, IL-1 signaling promoted expansion of antiviral CD8+ T cells and control of viral reactivation in the peritoneal cavity of a long-term infected host. Using a novel mouse model of T cell-specific IL-1 signaling deficiency, we found that the antiviral effects of IL-1 signaling were T cell extrinsic. Our study highlights a dynamic nature of host factors that shape the parameters of chronic gammaherpesvirus infection." @default.
• W4303423812 created "2022-10-07" @default.
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• W4303423812 date "2022-11-01" @default.
• W4303423812 modified "2023-09-30" @default.
• W4303423812 title "T cell-extrinsic IL-1 signaling controls long-term gammaherpesvirus infection by suppressing viral reactivation" @default.
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• W4303423812 doi "https://doi.org/10.1016/j.virol.2022.09.006" @default.
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