Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303520912> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4303520912 abstract "Abstract During tissue folding in developmental processes and monolayer migration in wound healing, epithelial cells undergo shape changes and move collectively. Recent experimental and numerical results suggested that these processes could leverage on the existence of both nematic (2–fold) and hexatic (6–fold) orientational order coexisting at different length scales within the same epithelial layer. Yet, how this remarkable example of multiscale organization in living matter is affected by the material properties of the cells and their substrate is presently unknown. In the current article, we experimentally address these questions in monolayers of Madin-Darby canine kidney cells (MDCK-II) having various cell density and molecular repertoire. At small length scales, confluent monolayers are characterized by a prominent hexatic order and nearly vanishing nematic order, independently on the presence of E-cadherin, the monolayer density, and the underlying substrate stiffness. All three properties, however, dramatically affect the organization of MDCK-II monolayers at large length scales, where nematic order becomes dominant over hexatic order. In particular, we find that the length scale at which nematic order prevails over hexatic order – here referred to as hexanematic crossover scale – strongly depends on cell-cell adhesions and correlates with the monolayer density. Our analysis sheds light on how the organization of epithelial layers is affected by the material and mechanical properties, and provides a robust approach for analyzing the tissue composition towards understanding developmental processes." @default.
- W4303520912 created "2022-10-08" @default.
- W4303520912 creator A5005890720 @default.
- W4303520912 creator A5037035676 @default.
- W4303520912 creator A5048191561 @default.
- W4303520912 creator A5070376252 @default.
- W4303520912 date "2022-10-07" @default.
- W4303520912 modified "2023-09-30" @default.
- W4303520912 title "Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density" @default.
- W4303520912 cites W1880645299 @default.
- W4303520912 cites W1979366429 @default.
- W4303520912 cites W1986802403 @default.
- W4303520912 cites W1994967651 @default.
- W4303520912 cites W2041012485 @default.
- W4303520912 cites W2056922353 @default.
- W4303520912 cites W2090534337 @default.
- W4303520912 cites W2091389429 @default.
- W4303520912 cites W2130735747 @default.
- W4303520912 cites W2155154349 @default.
- W4303520912 cites W2168147240 @default.
- W4303520912 cites W2173637151 @default.
- W4303520912 cites W2218510376 @default.
- W4303520912 cites W2397027267 @default.
- W4303520912 cites W2520869106 @default.
- W4303520912 cites W2599250996 @default.
- W4303520912 cites W2606063864 @default.
- W4303520912 cites W2606454966 @default.
- W4303520912 cites W2786248270 @default.
- W4303520912 cites W2795668489 @default.
- W4303520912 cites W2889062661 @default.
- W4303520912 cites W2962914316 @default.
- W4303520912 cites W2967768480 @default.
- W4303520912 cites W2982658925 @default.
- W4303520912 cites W3011550767 @default.
- W4303520912 cites W3023737870 @default.
- W4303520912 cites W3024726737 @default.
- W4303520912 cites W3027970407 @default.
- W4303520912 cites W3098569689 @default.
- W4303520912 cites W3108935548 @default.
- W4303520912 cites W3131704952 @default.
- W4303520912 cites W3133566862 @default.
- W4303520912 cites W3145684576 @default.
- W4303520912 cites W3174575177 @default.
- W4303520912 cites W3191252994 @default.
- W4303520912 cites W3215411645 @default.
- W4303520912 cites W4205244866 @default.
- W4303520912 cites W4210304720 @default.
- W4303520912 cites W4212772205 @default.
- W4303520912 cites W4221076451 @default.
- W4303520912 cites W4223976613 @default.
- W4303520912 doi "https://doi.org/10.1101/2022.10.07.511294" @default.
- W4303520912 hasPublicationYear "2022" @default.
- W4303520912 type Work @default.
- W4303520912 citedByCount "2" @default.
- W4303520912 countsByYear W43035209122023 @default.
- W4303520912 crossrefType "posted-content" @default.
- W4303520912 hasAuthorship W4303520912A5005890720 @default.
- W4303520912 hasAuthorship W4303520912A5037035676 @default.
- W4303520912 hasAuthorship W4303520912A5048191561 @default.
- W4303520912 hasAuthorship W4303520912A5070376252 @default.
- W4303520912 hasBestOaLocation W43035209121 @default.
- W4303520912 hasConcept C121332964 @default.
- W4303520912 hasConcept C12554922 @default.
- W4303520912 hasConcept C13274807 @default.
- W4303520912 hasConcept C159467904 @default.
- W4303520912 hasConcept C171250308 @default.
- W4303520912 hasConcept C185592680 @default.
- W4303520912 hasConcept C192562407 @default.
- W4303520912 hasConcept C26873012 @default.
- W4303520912 hasConcept C49040817 @default.
- W4303520912 hasConcept C7070889 @default.
- W4303520912 hasConcept C86803240 @default.
- W4303520912 hasConceptScore W4303520912C121332964 @default.
- W4303520912 hasConceptScore W4303520912C12554922 @default.
- W4303520912 hasConceptScore W4303520912C13274807 @default.
- W4303520912 hasConceptScore W4303520912C159467904 @default.
- W4303520912 hasConceptScore W4303520912C171250308 @default.
- W4303520912 hasConceptScore W4303520912C185592680 @default.
- W4303520912 hasConceptScore W4303520912C192562407 @default.
- W4303520912 hasConceptScore W4303520912C26873012 @default.
- W4303520912 hasConceptScore W4303520912C49040817 @default.
- W4303520912 hasConceptScore W4303520912C7070889 @default.
- W4303520912 hasConceptScore W4303520912C86803240 @default.
- W4303520912 hasLocation W43035209121 @default.
- W4303520912 hasOpenAccess W4303520912 @default.
- W4303520912 hasPrimaryLocation W43035209121 @default.
- W4303520912 hasRelatedWork W1986224449 @default.
- W4303520912 hasRelatedWork W2000049981 @default.
- W4303520912 hasRelatedWork W2015172468 @default.
- W4303520912 hasRelatedWork W2016098407 @default.
- W4303520912 hasRelatedWork W2070350940 @default.
- W4303520912 hasRelatedWork W2104534095 @default.
- W4303520912 hasRelatedWork W2351841670 @default.
- W4303520912 hasRelatedWork W2899084033 @default.
- W4303520912 hasRelatedWork W2994270459 @default.
- W4303520912 hasRelatedWork W3004125896 @default.
- W4303520912 isParatext "false" @default.
- W4303520912 isRetracted "false" @default.
- W4303520912 workType "article" @default.