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- W4303579043 endingPage "1993" @default.
- W4303579043 startingPage "1993" @default.
- W4303579043 abstract "Ascorbic acid, as a one of the basic exogenous vitamins, occurs in the body in the form of ascorbate, known for its strong antioxidant and anti-inflammatory properties. The presented review shows not only the importance of ascorbate as a free radical scavenger but also summarizes its antioxidant action based on other mechanisms, including the activation of intracellular antioxidant systems and its effect on the NFκB/TNFα pathway and apoptosis. Ascorbate interacts with small-molecule antioxidants, including tocopherol, glutathione, and thioredoxin; it can also stimulate biosynthesis and the activation of antioxidant enzymes, such as superoxide dismutase, catalase, or glutathione peroxidase. Moreover, ascorbate promotes the activity of transcription factors (Nrf2, Ref-1, AP-1), which enables the expression of genes encoding antioxidant proteins. Additionally, it supports the action of other exogenous antioxidants, mainly polyphenols. In this regard, both DNA, proteins, and lipids are protected against oxidation, leading to an inflammatory reaction and even cell death. Although ascorbate has strong antioxidant properties, it can also have pro-oxidant effects in the presence of free transition metals. However, its role in the prevention of DNA mutation, inflammation, and cell apoptosis, especially in relation to cancer cells, is controversial." @default.
- W4303579043 created "2022-10-08" @default.
- W4303579043 creator A5009562756 @default.
- W4303579043 creator A5045227473 @default.
- W4303579043 date "2022-10-07" @default.
- W4303579043 modified "2023-10-18" @default.
- W4303579043 title "Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid" @default.
- W4303579043 cites W1440495760 @default.
- W4303579043 cites W1491553594 @default.
- W4303579043 cites W159669330 @default.
- W4303579043 cites W1812661065 @default.
- W4303579043 cites W1828830410 @default.
- W4303579043 cites W1903515770 @default.
- W4303579043 cites W1909885733 @default.
- W4303579043 cites W1932728046 @default.
- W4303579043 cites W1941885653 @default.
- W4303579043 cites W1964373025 @default.
- W4303579043 cites W1969375160 @default.
- W4303579043 cites W1975078627 @default.
- W4303579043 cites W1977335868 @default.
- W4303579043 cites W1978025607 @default.
- W4303579043 cites W1978122209 @default.
- W4303579043 cites W1978407431 @default.
- W4303579043 cites W1979876566 @default.
- W4303579043 cites W1980812423 @default.
- W4303579043 cites W1982241628 @default.
- W4303579043 cites W1982304481 @default.
- W4303579043 cites W1984372443 @default.
- W4303579043 cites W1986222438 @default.
- W4303579043 cites W1986237416 @default.
- W4303579043 cites W1987695434 @default.
- W4303579043 cites W1988130582 @default.
- W4303579043 cites W1989641666 @default.
- W4303579043 cites W1993909890 @default.
- W4303579043 cites W1994253596 @default.
- W4303579043 cites W1994318934 @default.
- W4303579043 cites W1994710185 @default.
- W4303579043 cites W1995625263 @default.
- W4303579043 cites W1998293871 @default.
- W4303579043 cites W2000143363 @default.
- W4303579043 cites W2001094865 @default.
- W4303579043 cites W2002667241 @default.
- W4303579043 cites W2010150587 @default.
- W4303579043 cites W2011094327 @default.
- W4303579043 cites W2013160447 @default.
- W4303579043 cites W2013833448 @default.
- W4303579043 cites W2014411801 @default.
- W4303579043 cites W2016923091 @default.
- W4303579043 cites W2016974821 @default.
- W4303579043 cites W2017173144 @default.
- W4303579043 cites W2017292503 @default.
- W4303579043 cites W2017657232 @default.
- W4303579043 cites W2025112128 @default.
- W4303579043 cites W2025587230 @default.
- W4303579043 cites W2026517317 @default.
- W4303579043 cites W2030477444 @default.
- W4303579043 cites W2032935857 @default.
- W4303579043 cites W2036910654 @default.
- W4303579043 cites W2037551449 @default.
- W4303579043 cites W2038419553 @default.
- W4303579043 cites W2041696139 @default.
- W4303579043 cites W2042430376 @default.
- W4303579043 cites W2042936114 @default.
- W4303579043 cites W2044096559 @default.
- W4303579043 cites W2044985089 @default.
- W4303579043 cites W2045492720 @default.
- W4303579043 cites W2047435448 @default.
- W4303579043 cites W2051424238 @default.
- W4303579043 cites W2051830689 @default.
- W4303579043 cites W2052013972 @default.
- W4303579043 cites W2057952781 @default.
- W4303579043 cites W2060682497 @default.
- W4303579043 cites W2062971532 @default.
- W4303579043 cites W2063795296 @default.
- W4303579043 cites W2064451393 @default.
- W4303579043 cites W2064452102 @default.
- W4303579043 cites W2064936207 @default.
- W4303579043 cites W2067200560 @default.
- W4303579043 cites W2069602599 @default.
- W4303579043 cites W2069932077 @default.
- W4303579043 cites W2070994569 @default.
- W4303579043 cites W2072801940 @default.
- W4303579043 cites W2084659761 @default.
- W4303579043 cites W2084980756 @default.
- W4303579043 cites W2085143181 @default.
- W4303579043 cites W2085306532 @default.
- W4303579043 cites W2085461619 @default.
- W4303579043 cites W2089195757 @default.
- W4303579043 cites W2090508099 @default.
- W4303579043 cites W2091452408 @default.
- W4303579043 cites W2093123316 @default.
- W4303579043 cites W2093363685 @default.
- W4303579043 cites W2096456417 @default.
- W4303579043 cites W2096877350 @default.
- W4303579043 cites W2097768016 @default.
- W4303579043 cites W2104939665 @default.
- W4303579043 cites W2107739703 @default.
- W4303579043 cites W2108345886 @default.