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- W4303613893 abstract "Abstract Mice are the most commonly used model animals for itch research and for development of antiitch drugs. Most labs manually quantify mouse scratching behavior to assess itch intensity. This process is labor-intensive and limits large-scale genetic or drug screenings. In this study, we developed a new system, Scratch-AID ( A utomatic I tch D etection), which could automatically identify and quantify mouse scratching behavior with high accuracy. Our system included a custom-designed videotaping box to ensure high-quality and replicable mouse behavior recording and a convolutional recurrent neural network (CRNN) trained with frame-labeled mouse scratching behavior videos, induced by nape injection of chloroquine (CQ). The best trained network achieved 97.6% recall and 96.9% precision on previously unseen test videos. Remarkably, Scratch-AID could reliably identify scratching behavior in other major mouse itch models, including the acute cheek model, the histaminergic model, and a chronic itch model. Moreover, our system detected significant differences in scratching behavior between control and mice treated with an anti-itch drug. Taken together, we have established a novel deep learning-based system that is ready to replace manual quantification for mouse scratching behavior in different itch models and for drug screening." @default.
- W4303613893 created "2022-10-08" @default.
- W4303613893 creator A5037128397 @default.
- W4303613893 creator A5042173280 @default.
- W4303613893 date "2022-10-07" @default.
- W4303613893 modified "2023-09-27" @default.
- W4303613893 title "Scratch-AID: A Deep-learning Based System for Automatic Detection of Mouse Scratching Behavior with High Accuracy" @default.
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- W4303613893 doi "https://doi.org/10.1101/2022.10.07.511352" @default.
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