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- W4303614030 abstract "Abstract Stem cell differentiation requires dramatic changes in gene expression and global remodeling of chromatin architecture. How and when chromatin remodels relative to the transcriptional, behavioral, and morphological changes during differentiation remain unclear, particularly in an intact tissue context. Here, we develop a quantitative pipeline which leverages fluorescently-tagged histones and longitudinal imaging to track large-scale chromatin compaction changes within individual cells in a live mouse. Applying this pipeline to epidermal stem cells, we reveal that cell-to-cell chromatin compaction heterogeneity within the stem cell compartment emerges independent of cell cycle status, and instead is reflective of differentiation status. Chromatin compaction state gradually transitions over days as differentiating cells exit the stem cell compartment. Moreover, establishing live imaging of keratin-10 nascent RNA, which marks the onset of stem cell differentiation, we find that keratin-10 transcription is highly dynamic and largely precedes the global chromatin compaction changes associated with differentiation. Together, these analyses reveal that stem cell differentiation involves dynamic transcriptional states and gradual chromatin rearrangement." @default.
- W4303614030 created "2022-10-08" @default.
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- W4303614030 date "2022-10-07" @default.
- W4303614030 modified "2023-10-16" @default.
- W4303614030 title "Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation <i>in vivo</i>" @default.
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- W4303614030 doi "https://doi.org/10.1101/2022.10.07.511316" @default.
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