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- W4303628774 endingPage "3143" @default.
- W4303628774 startingPage "3143" @default.
- W4303628774 abstract "Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental molecules such as Wnt, ephrins, and semaphorins are acknowledged as central players in the proper growth of a biological system. Their receptors and ligands are expressed in a wide variety in both neurons and glial cells, which are implicated in pain development, maintenance, and resolution. Thereby, it is not surprising that the impairment of those pathways affects the activities and functions of the entire cell. Evidence indicates aberrant activation of their pathways in the nervous system in rodent models of chronic pain. In those conditions, Wnt, ephrin, and semaphorin signaling participate in enhancing neuronal excitability, peripheral sensitization, synaptic plasticity, and the production and release of inflammatory cytokines. This review summarizes the current knowledge on three main developmental pathways and their mechanisms linked with the pathogenesis and progression of pain, considering their impacts on neuronal and glial cells in experimental animal models. Elucidations of the downstream pathways may provide a new mechanism for the involvement of Wnt, ephrin, and semaphorin pathways in pain chronicity." @default.
- W4303628774 created "2022-10-08" @default.
- W4303628774 creator A5050455871 @default.
- W4303628774 creator A5062543756 @default.
- W4303628774 date "2022-10-06" @default.
- W4303628774 modified "2023-10-01" @default.
- W4303628774 title "Axon Guidance Molecules and Pain" @default.
- W4303628774 cites W1171081979 @default.
- W4303628774 cites W144423133 @default.
- W4303628774 cites W1486634172 @default.
- W4303628774 cites W1524233852 @default.
- W4303628774 cites W1563901861 @default.
- W4303628774 cites W1568119668 @default.
- W4303628774 cites W1577712319 @default.
- W4303628774 cites W1584018958 @default.
- W4303628774 cites W1600863966 @default.
- W4303628774 cites W1664105603 @default.
- W4303628774 cites W1756898524 @default.
- W4303628774 cites W1787206380 @default.
- W4303628774 cites W1829237824 @default.
- W4303628774 cites W1838548664 @default.
- W4303628774 cites W1915231496 @default.
- W4303628774 cites W1919241967 @default.
- W4303628774 cites W1966219913 @default.
- W4303628774 cites W1969443028 @default.
- W4303628774 cites W1970360986 @default.
- W4303628774 cites W1972894972 @default.
- W4303628774 cites W1973256550 @default.
- W4303628774 cites W1974352595 @default.
- W4303628774 cites W1975858506 @default.
- W4303628774 cites W1979892425 @default.
- W4303628774 cites W1979988425 @default.
- W4303628774 cites W1980251112 @default.
- W4303628774 cites W1980789245 @default.
- W4303628774 cites W1982763326 @default.
- W4303628774 cites W1984434438 @default.
- W4303628774 cites W1986606911 @default.
- W4303628774 cites W1986824560 @default.
- W4303628774 cites W1988521127 @default.
- W4303628774 cites W1991701428 @default.
- W4303628774 cites W1992085076 @default.
- W4303628774 cites W1992187858 @default.
- W4303628774 cites W1994716934 @default.
- W4303628774 cites W1994912172 @default.
- W4303628774 cites W1995549311 @default.
- W4303628774 cites W1996131261 @default.
- W4303628774 cites W1996493203 @default.
- W4303628774 cites W1999118391 @default.
- W4303628774 cites W1999966549 @default.
- W4303628774 cites W2002378079 @default.
- W4303628774 cites W2003069734 @default.
- W4303628774 cites W2003190203 @default.
- W4303628774 cites W2003213153 @default.
- W4303628774 cites W2003615946 @default.
- W4303628774 cites W2003766638 @default.
- W4303628774 cites W2004301965 @default.
- W4303628774 cites W2004518871 @default.
- W4303628774 cites W2005871788 @default.
- W4303628774 cites W2005901996 @default.
- W4303628774 cites W2012070523 @default.
- W4303628774 cites W2017020944 @default.
- W4303628774 cites W2019720659 @default.
- W4303628774 cites W2021109833 @default.
- W4303628774 cites W2026854632 @default.
- W4303628774 cites W2029487310 @default.
- W4303628774 cites W2031930713 @default.
- W4303628774 cites W2033116719 @default.
- W4303628774 cites W2033649360 @default.
- W4303628774 cites W2033706178 @default.
- W4303628774 cites W2034064964 @default.
- W4303628774 cites W2036908922 @default.
- W4303628774 cites W2037761116 @default.
- W4303628774 cites W2037985138 @default.
- W4303628774 cites W2038394965 @default.
- W4303628774 cites W2038999076 @default.
- W4303628774 cites W2039064542 @default.
- W4303628774 cites W2043732175 @default.
- W4303628774 cites W2044450732 @default.
- W4303628774 cites W2045694632 @default.
- W4303628774 cites W2046019936 @default.
- W4303628774 cites W2046060396 @default.
- W4303628774 cites W2046239707 @default.
- W4303628774 cites W2046479957 @default.
- W4303628774 cites W2047166961 @default.
- W4303628774 cites W2047989410 @default.
- W4303628774 cites W2048425686 @default.
- W4303628774 cites W2048841778 @default.
- W4303628774 cites W2051405592 @default.
- W4303628774 cites W2052401001 @default.
- W4303628774 cites W2052689712 @default.
- W4303628774 cites W2054376706 @default.
- W4303628774 cites W2055174533 @default.
- W4303628774 cites W2055510343 @default.
- W4303628774 cites W2055613750 @default.
- W4303628774 cites W2056745170 @default.
- W4303628774 cites W2057767129 @default.
- W4303628774 cites W2058527604 @default.
- W4303628774 cites W2058544036 @default.