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- W4303628968 endingPage "3123" @default.
- W4303628968 startingPage "3123" @default.
- W4303628968 abstract "Most conventional incubators used in cell culture do not regulate O2 levels, making the headspace O2 concentration ~18%. In contrast, most human tissues are exposed to 2–6% O2 (physioxia) in vivo. Accumulating evidence has shown that such hyperoxic conditions in standard cell culture practices affect a variety of biological processes. In this review, we discuss how supraphysiological O2 levels affect reactive oxygen species (ROS) metabolism and redox homeostasis, gene expression, replicative lifespan, cellular respiration, and mitochondrial dynamics. Furthermore, we present evidence demonstrating how hyperoxic cell culture conditions fail to recapitulate the physiological and pathological behavior of tissues in vivo, including cases of how O2 alters the cellular response to drugs, hormones, and toxicants. We conclude that maintaining physioxia in cell culture is imperative in order to better replicate in vivo-like tissue physiology and pathology, and to avoid artifacts in research involving cell culture." @default.
- W4303628968 created "2022-10-08" @default.
- W4303628968 creator A5011405524 @default.
- W4303628968 creator A5019254000 @default.
- W4303628968 creator A5069548274 @default.
- W4303628968 creator A5088418122 @default.
- W4303628968 date "2022-10-04" @default.
- W4303628968 modified "2023-10-18" @default.
- W4303628968 title "Supraphysiological Oxygen Levels in Mammalian Cell Culture: Current State and Future Perspectives" @default.
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