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- W4303650478 abstract "Abstract Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods have focused only on individuals with one primary continental ancestry, thus poorly accommodating recently-admixed individuals. Here, we develop GAUDI, a novel penalized-regression-based method specifically designed for admixed individuals by explicitly modeling ancestry-specific effects and jointly estimating ancestry-shared effects. We demonstrate marked advantages of GAUDI over other methods through comprehensive simulation and real data analyses." @default.
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- W4303650478 date "2022-10-08" @default.
- W4303650478 modified "2023-10-06" @default.
- W4303650478 title "Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI" @default.
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- W4303650478 doi "https://doi.org/10.1101/2022.10.06.511219" @default.
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