Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303684539> ?p ?o ?g. }
- W4303684539 abstract "Abstract Background Candida glabrata is an opportunistic yeast pathogen thought to have a large genetic and phenotypic diversity and a highly plastic genome. However, the lack of chromosome-level genome assemblies representing this diversity limits our ability to accurately establish how chromosomal structure and gene content vary across strains. Results Here, we expanded publicly available assemblies by using long-read sequencing technologies in twelve diverse strains, obtaining a final set of twenty-one chromosome-level genomes spanning the known C. glabrata diversity. Using comparative approaches, we inferred variation in chromosome structure and determined the pan-genome, including an analysis of the adhesin gene repertoire. Our analysis uncovered four new adhesin orthogroups and inferred a rich ancestral adhesion repertoire, which was subsequently shaped through a still ongoing process of gene loss, gene duplication, and gene conversion. Conclusions C. glabrata has a largely stable pan-genome except for a highly variable subset of genes encoding cell wall-associated functions. Adhesin repertoire was established for each strain and showed variability among clades." @default.
- W4303684539 created "2022-10-09" @default.
- W4303684539 creator A5003394700 @default.
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- W4303684539 creator A5064295564 @default.
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- W4303684539 date "2022-10-08" @default.
- W4303684539 modified "2023-10-09" @default.
- W4303684539 title "Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata" @default.
- W4303684539 cites W1594622192 @default.
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- W4303684539 cites W1767772592 @default.
- W4303684539 cites W1935757583 @default.
- W4303684539 cites W1964612763 @default.
- W4303684539 cites W1969353942 @default.
- W4303684539 cites W1973133163 @default.
- W4303684539 cites W1982855075 @default.
- W4303684539 cites W1983545829 @default.
- W4303684539 cites W1987423713 @default.
- W4303684539 cites W2002032208 @default.
- W4303684539 cites W2002850151 @default.
- W4303684539 cites W2003094568 @default.
- W4303684539 cites W2009119978 @default.
- W4303684539 cites W2013150534 @default.
- W4303684539 cites W2016306656 @default.
- W4303684539 cites W2070146936 @default.
- W4303684539 cites W2075016274 @default.
- W4303684539 cites W2088182993 @default.
- W4303684539 cites W2090392412 @default.
- W4303684539 cites W2094285298 @default.
- W4303684539 cites W2095685450 @default.
- W4303684539 cites W2099753867 @default.
- W4303684539 cites W2100246797 @default.
- W4303684539 cites W2101291993 @default.
- W4303684539 cites W2102652793 @default.
- W4303684539 cites W2105191441 @default.
- W4303684539 cites W2105649156 @default.
- W4303684539 cites W2108108770 @default.
- W4303684539 cites W2111647009 @default.
- W4303684539 cites W2115888213 @default.
- W4303684539 cites W2120902911 @default.
- W4303684539 cites W2124388496 @default.
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- W4303684539 cites W2130530163 @default.
- W4303684539 cites W2131271579 @default.
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- W4303684539 cites W2141294282 @default.
- W4303684539 cites W2148239117 @default.
- W4303684539 cites W2150550043 @default.
- W4303684539 cites W2155403267 @default.
- W4303684539 cites W2164429184 @default.
- W4303684539 cites W2194172909 @default.
- W4303684539 cites W2195724570 @default.
- W4303684539 cites W2211508526 @default.
- W4303684539 cites W2265623652 @default.
- W4303684539 cites W2277953252 @default.
- W4303684539 cites W2337229959 @default.
- W4303684539 cites W2397469828 @default.
- W4303684539 cites W2530772399 @default.
- W4303684539 cites W2575750030 @default.
- W4303684539 cites W2582800429 @default.
- W4303684539 cites W2586557085 @default.
- W4303684539 cites W2912990441 @default.
- W4303684539 cites W2943673889 @default.
- W4303684539 cites W2950354111 @default.
- W4303684539 cites W2950891420 @default.
- W4303684539 cites W2951278111 @default.
- W4303684539 cites W2951922435 @default.
- W4303684539 cites W2952366981 @default.
- W4303684539 cites W2952386282 @default.
- W4303684539 cites W2988396470 @default.
- W4303684539 cites W2990344913 @default.
- W4303684539 cites W2992976869 @default.
- W4303684539 cites W2993963316 @default.
- W4303684539 cites W2994888090 @default.
- W4303684539 cites W3008280539 @default.
- W4303684539 cites W3092713351 @default.
- W4303684539 cites W3125215968 @default.
- W4303684539 cites W3134546133 @default.
- W4303684539 cites W3164211868 @default.
- W4303684539 cites W3211945695 @default.
- W4303684539 cites W3217434171 @default.
- W4303684539 cites W4200047626 @default.
- W4303684539 cites W4205797821 @default.
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- W4303684539 doi "https://doi.org/10.1186/s12915-022-01412-1" @default.
- W4303684539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36209154" @default.
- W4303684539 hasPublicationYear "2022" @default.
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