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- W4303685046 abstract "Background: Volumetric absorptive microsampling may reduce the blood collection burden associated with therapeutic drug monitoring of immunosuppression to prevent organ transplant rejection. This work describes the development of a laboratory and analytical technique for quantifying tacrolimus and mycophenolic acid (MPA) from the Tasso-M20™ in human whole blood using bead-based impact-assisted extraction. Results: The sampled blood volume was accurate with estimated volumes within <2% of the expected 20 μl. Recovery using impact-assisted extraction was 73-87% for MPA and 100% for tacrolimus and was hematocrit-independent for both analytes. The LC-MS/MS assay is precise and accurate within the acceptance criteria of 15%. Conclusion: The sampling and extraction procedures allowed for accurate quantification of tacrolimus and MPA. Exploration of abuse scenarios identified important education points for patients conducting home-based sample collections in the future." @default.
- W4303685046 created "2022-10-09" @default.
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- W4303685046 date "2022-09-01" @default.
- W4303685046 modified "2023-09-23" @default.
- W4303685046 title "Application of a new volumetric microsampling device for quantitative bioanalysis of immunosuppression" @default.
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- W4303685046 doi "https://doi.org/10.4155/bio-2022-0155" @default.
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