Matches in SemOpenAlex for { <https://semopenalex.org/work/W4303832965> ?p ?o ?g. }
- W4303832965 endingPage "257" @default.
- W4303832965 startingPage "243" @default.
- W4303832965 abstract "One carbon metabolism (1CM) can be defined as the transfer of a carbon unit from one metabolite to another and its replenishment by different sources of labile methyl-group nutrients: primarily choline, methionine, betaine, and serine. This flow of carbon units allows the biosynthesis of nucleotides, amino acids, formylated methionyl-tRNA, polyamines, glutathione, phospholipids, detoxification reactions, maintenance of the redox status and the concentration of NAD, and methylation reactions including epigenetic modifications. That is, 1CM functions as a nutrient sensor and integrator of cellular metabolism. A critical process in 1CM is the synthesis of S-adenosylmethionine (SAMe), the source of essentially all the hundreds of millions of daily methyl transfer reactions in a cell. This versatility of SAMe imposes a tight control in its synthesis and catabolism. Much of our knowledge concerning 1CM has been gained from studies in the production and prevention of nonalcoholic fatty liver disease (NAFLD). Here, we discuss in detail the function of the most important enzymes for their quantitative contribution to maintaining the flux of carbon units through 1CM in the liver and discuss how alterations in their enzymatic activity contribute to the development of NAFLD. Next, we discuss NAFLD subtypes based on serum lipidomic profiles with different risk of cardiovascular disease. Among the latter, we highlight the so-called subtype A for its serum lipidomic profile phenocopying that of mice deficient in SAMe synthesis and because its high frequency (about 50% of the NAFLD patients)." @default.
- W4303832965 created "2022-10-09" @default.
- W4303832965 creator A5013928900 @default.
- W4303832965 creator A5020455290 @default.
- W4303832965 creator A5036819711 @default.
- W4303832965 creator A5038446855 @default.
- W4303832965 creator A5054255043 @default.
- W4303832965 creator A5079688872 @default.
- W4303832965 date "2022-10-04" @default.
- W4303832965 modified "2023-10-18" @default.
- W4303832965 title "One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes" @default.
- W4303832965 cites W1490329277 @default.
- W4303832965 cites W1503760388 @default.
- W4303832965 cites W1523155649 @default.
- W4303832965 cites W1839930114 @default.
- W4303832965 cites W1891008845 @default.
- W4303832965 cites W1893515444 @default.
- W4303832965 cites W1965283476 @default.
- W4303832965 cites W1967206613 @default.
- W4303832965 cites W1973272888 @default.
- W4303832965 cites W1976428197 @default.
- W4303832965 cites W1988457908 @default.
- W4303832965 cites W1989449722 @default.
- W4303832965 cites W2002613261 @default.
- W4303832965 cites W2014023229 @default.
- W4303832965 cites W2018404966 @default.
- W4303832965 cites W2024342994 @default.
- W4303832965 cites W2033216272 @default.
- W4303832965 cites W2033957878 @default.
- W4303832965 cites W2035970641 @default.
- W4303832965 cites W2044682380 @default.
- W4303832965 cites W2051522090 @default.
- W4303832965 cites W2052716733 @default.
- W4303832965 cites W2054534199 @default.
- W4303832965 cites W2057210916 @default.
- W4303832965 cites W2057820609 @default.
- W4303832965 cites W2067740038 @default.
- W4303832965 cites W2068264995 @default.
- W4303832965 cites W2073086944 @default.
- W4303832965 cites W2073335871 @default.
- W4303832965 cites W2073695538 @default.
- W4303832965 cites W2085645589 @default.
- W4303832965 cites W2087355759 @default.
- W4303832965 cites W2089401171 @default.
- W4303832965 cites W2089455486 @default.
- W4303832965 cites W2092412521 @default.
- W4303832965 cites W2104277391 @default.
- W4303832965 cites W2108450638 @default.
- W4303832965 cites W2122500634 @default.
- W4303832965 cites W2126714484 @default.
- W4303832965 cites W2127281349 @default.
- W4303832965 cites W2135055848 @default.
- W4303832965 cites W2137516998 @default.
- W4303832965 cites W2140483277 @default.
- W4303832965 cites W2142983041 @default.
- W4303832965 cites W2150020322 @default.
- W4303832965 cites W2156246748 @default.
- W4303832965 cites W2160173410 @default.
- W4303832965 cites W2164799069 @default.
- W4303832965 cites W2274120444 @default.
- W4303832965 cites W2328999771 @default.
- W4303832965 cites W2341568598 @default.
- W4303832965 cites W2514898138 @default.
- W4303832965 cites W2518901523 @default.
- W4303832965 cites W2581693313 @default.
- W4303832965 cites W2594205132 @default.
- W4303832965 cites W2605431828 @default.
- W4303832965 cites W2605754375 @default.
- W4303832965 cites W2614590942 @default.
- W4303832965 cites W2733406733 @default.
- W4303832965 cites W2761787658 @default.
- W4303832965 cites W2767233119 @default.
- W4303832965 cites W2768361988 @default.
- W4303832965 cites W2801297606 @default.
- W4303832965 cites W2808619307 @default.
- W4303832965 cites W2810423511 @default.
- W4303832965 cites W2888859009 @default.
- W4303832965 cites W2890426109 @default.
- W4303832965 cites W2899024699 @default.
- W4303832965 cites W2899389750 @default.
- W4303832965 cites W2944060116 @default.
- W4303832965 cites W2951052348 @default.
- W4303832965 cites W2955514214 @default.
- W4303832965 cites W2968636820 @default.
- W4303832965 cites W3004644667 @default.
- W4303832965 cites W3006028518 @default.
- W4303832965 cites W3015361084 @default.
- W4303832965 cites W3030074493 @default.
- W4303832965 cites W3036522535 @default.
- W4303832965 cites W3139202285 @default.
- W4303832965 cites W3148732151 @default.
- W4303832965 cites W3211734656 @default.
- W4303832965 cites W4205424335 @default.
- W4303832965 cites W4211242412 @default.
- W4303832965 cites W4214496831 @default.
- W4303832965 cites W4230795754 @default.
- W4303832965 cites W92889 @default.
- W4303832965 doi "https://doi.org/10.3390/livers2040020" @default.