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• W4303946056 endingPage "11998" @default.
• W4303946056 startingPage "11998" @default.
• W4303946056 abstract "The quality of the lubricant between cartilaginous joint surfaces impacts the joint’s mechanistic properties. In this study, we define the biochemical, ultrastructural, and tribological signatures of synovial fluids (SF) from patients with degenerative (osteoarthritis-OA) or inflammatory (rheumatoid arthritis-RA) joint pathologies in comparison with SF from healthy subjects. Phospholipid (PL) concentration in SF increased in pathological contexts, but the proportion PL relative to the overall lipids decreased. Subtle changes in PL chain composition were attributed to the inflammatory state. Transmission electron microscopy showed the occurrence of large multilamellar synovial extracellular vesicles (EV) filled with glycoprotein gel in healthy subjects. Synovial extracellular vesicle structure was altered in SF from OA and RA patients. RA samples systematically showed lower viscosity than healthy samples under a hydrodynamic lubricating regimen whereas OA samples showed higher viscosity. In turn, under a boundary regimen, cartilage surfaces in both pathological situations showed high wear and friction coefficients. Thus, we found a difference in the biochemical, tribological, and ultrastructural properties of synovial fluid in healthy people and patients with osteoarthritis and arthritis of the joints, and that large, multilamellar vesicles are essential for good boundary lubrication by ensuring a ball-bearing effect and limiting the destruction of lipid layers at the cartilage surface." @default.
• W4303946056 created "2022-10-10" @default.
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• W4303946056 date "2022-10-09" @default.
• W4303946056 modified "2023-10-01" @default.
• W4303946056 title "Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances" @default.
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• W4303946056 doi "https://doi.org/10.3390/ijms231911998" @default.
• W4303946056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36233300" @default.
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